Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones
Publication
, Journal Article
Timmerman, JC; Widenhoefer, RA
Published in: Advanced Synthesis and Catalysis
November 16, 2015
The cationic gold phosphine complex [(o-biphenylPCy2)Au(NCMe)]+ SbF6- catalyzes the intermolecular, anti-Markovnikov hydroamination of methylenecyclopropanes (MCPs) with 2-pyridones at 80 C. The transformation was effective for a range of pyridones and for monosubstituted and cis- and trans-disubstituted MCPs to form 1-cyclopropylmethyl-2-pyridones with excellent regio- and diastereoselectivity in moderate to good yields.
Duke Scholars
Published In
Advanced Synthesis and Catalysis
DOI
EISSN
1615-4169
ISSN
1615-4150
Publication Date
November 16, 2015
Volume
357
Issue
16-17
Start / End Page
3703 / 3706
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 0904 Chemical Engineering
- 0305 Organic Chemistry
- 0302 Inorganic Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Timmerman, J. C., & Widenhoefer, R. A. (2015). Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones. Advanced Synthesis and Catalysis, 357(16–17), 3703–3706. https://doi.org/10.1002/adsc.201500866
Timmerman, J. C., and R. A. Widenhoefer. “Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones.” Advanced Synthesis and Catalysis 357, no. 16–17 (November 16, 2015): 3703–6. https://doi.org/10.1002/adsc.201500866.
Timmerman JC, Widenhoefer RA. Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones. Advanced Synthesis and Catalysis. 2015 Nov 16;357(16–17):3703–6.
Timmerman, J. C., and R. A. Widenhoefer. “Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones.” Advanced Synthesis and Catalysis, vol. 357, no. 16–17, Nov. 2015, pp. 3703–06. Scopus, doi:10.1002/adsc.201500866.
Timmerman JC, Widenhoefer RA. Gold-Catalyzed Intermolecular anti-Markovnikov Hydroamination of Methylenecyclopropanes with 2-Pyridones. Advanced Synthesis and Catalysis. 2015 Nov 16;357(16–17):3703–3706.
Published In
Advanced Synthesis and Catalysis
DOI
EISSN
1615-4169
ISSN
1615-4150
Publication Date
November 16, 2015
Volume
357
Issue
16-17
Start / End Page
3703 / 3706
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 0904 Chemical Engineering
- 0305 Organic Chemistry
- 0302 Inorganic Chemistry