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Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.

Publication ,  Journal Article
Soliman, AS; Lo, A-C; Banerjee, M; El-Ghawalby, N; Khaled, HM; Bayoumi, S; Seifeldin, IA; Abdel-Aziz, A; Abbruzzese, JL; Greenson, JK; Hamilton, SR
Published in: Carcinogenesis
August 2007

BACKGROUND: Variations in genetic mutations in pancreatic carcinoma between different geographical regions have not been studied extensively, especially in developing countries where pancreatic cancer is relatively rare. METHODS: We studied the molecular pathology of 54 pancreatic adenocarcinomas from Egyptian patients residing in a heavily polluted region of the eastern Nile River delta and compared the findings with 45 tumors from patients residing in low-pollution regions. RESULTS: Rates of K-ras mutation in codon 12 and of p53 mutation in exons 5-8 were higher in tumors of patients from the high-pollution region as compared with the low-pollution regions (61.5 versus 34.2%, respectively, for K-ras, P = 0.01; 25.9 versus 11.6%, respectively, for p53, P = 0.08). There were also distinct differences in the specific types of K-ras and p53 mutations between the two regions. The ratio of G-to-T k-ras transversion mutation (codon 12) relative to wild-type was significantly higher in tumors from the high-pollution region (0.90) than tumors from the non-pollution site (0.28) (P = 0.03). Relative to tumors with wild-type, the ratio of p53 mutations in exons 5, 7 or 8 to wild-type in tumors from the high-pollution region was significantly higher than the ratio from the non-pollution site (0.28 versus 0.03, P = 0.01). Logistic regression showed that G-to-T transversion mutation in K-ras was predicted by the region of residence of the patients. CONCLUSIONS: Our study reveals that there are differences in the frequencies and types of K-ras and p53 mutations found in pancreatic adenocarcinomas of patients in high-pollution and low-pollution regions in Egypt and suggests that environmental factors may explain these differences. We speculate that gene-environment interactions in pancreatic carcinogenesis also occur in other populations.

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Published In

Carcinogenesis

DOI

ISSN

0143-3334

Publication Date

August 2007

Volume

28

Issue

8

Start / End Page

1794 / 1799

Location

England

Related Subject Headings

  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Genes, ras
  • Genes, p53
  • Female
 

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Soliman, A. S., Lo, A.-C., Banerjee, M., El-Ghawalby, N., Khaled, H. M., Bayoumi, S., … Hamilton, S. R. (2007). Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution. Carcinogenesis, 28(8), 1794–1799. https://doi.org/10.1093/carcin/bgm138
Soliman, Amr S., An-Chi Lo, Mousumi Banerjee, Nabih El-Ghawalby, Hussein M. Khaled, Sherif Bayoumi, Ibrahim A. Seifeldin, et al. “Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.Carcinogenesis 28, no. 8 (August 2007): 1794–99. https://doi.org/10.1093/carcin/bgm138.
Soliman AS, Lo A-C, Banerjee M, El-Ghawalby N, Khaled HM, Bayoumi S, et al. Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution. Carcinogenesis. 2007 Aug;28(8):1794–9.
Soliman, Amr S., et al. “Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.Carcinogenesis, vol. 28, no. 8, Aug. 2007, pp. 1794–99. Pubmed, doi:10.1093/carcin/bgm138.
Soliman AS, Lo A-C, Banerjee M, El-Ghawalby N, Khaled HM, Bayoumi S, Seifeldin IA, Abdel-Aziz A, Abbruzzese JL, Greenson JK, Hamilton SR. Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution. Carcinogenesis. 2007 Aug;28(8):1794–1799.
Journal cover image

Published In

Carcinogenesis

DOI

ISSN

0143-3334

Publication Date

August 2007

Volume

28

Issue

8

Start / End Page

1794 / 1799

Location

England

Related Subject Headings

  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Genes, ras
  • Genes, p53
  • Female