Skip to main content
Journal cover image

Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy?

Publication ,  Journal Article
Aloia, TA; Lee, JE; Vauthey, J-N; Abdalla, EK; Wolff, RA; Varadhachary, GR; Abbruzzese, JL; Crane, CH; Evans, DB; Pisters, PWT
Published in: J Am Coll Surg
March 2007

BACKGROUND: Delayed recovery after pancreaticoduodenectomy (PD) is believed to preclude adjuvant therapy for approximately 30% of patients who undergo elective PD as initial treatment for pancreatic adenocarcinoma. This study reexamined the frequency of delayed recovery and assessed other factors associated with adjuvant therapy administration after PD at a high-volume center. STUDY DESIGN: Preoperative and perioperative variables were reviewed in a consecutive series of 85 patients with pancreatic adenocarcinoma undergoing PD without preoperative chemotherapy or radiotherapy from 1990 to 2004. RESULTS: Study groups included patients undergoing emergency PD (group 1, n=13); elective PD with good preoperative Eastern Cooperative Oncology Group (ECOG) performance status (PS) (group 2, ECOG PS: 0 to 1, n=63); and elective PD with marginal preoperative PS (group 3, ECOG PS: 2 to 3, n=9). Delayed recovery of PS precluded adjuvant therapy in 23% of patients in group 1, 6% of patients in group 2, and 44% of patients in group 3 (p=0.0001). CONCLUSIONS: The impact of delayed recovery after PD on the delivery of adjuvant therapy depends on the urgency of surgery and the preoperative PS. For patients with good preoperative PS who undergo elective PD at a high-volume center, it is uncommon for delayed recovery to preclude delivery of adjuvant therapy.

Duke Scholars

Published In

J Am Coll Surg

DOI

ISSN

1072-7515

Publication Date

March 2007

Volume

204

Issue

3

Start / End Page

347 / 355

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Surgery
  • Risk Factors
  • Radiotherapy, Adjuvant
  • Prospective Studies
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Aloia, T. A., Lee, J. E., Vauthey, J.-N., Abdalla, E. K., Wolff, R. A., Varadhachary, G. R., … Pisters, P. W. T. (2007). Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy? J Am Coll Surg, 204(3), 347–355. https://doi.org/10.1016/j.jamcollsurg.2006.12.011
Aloia, Thomas A., Jeffrey E. Lee, Jean-Nicolas Vauthey, Eddie K. Abdalla, Robert A. Wolff, Gauri R. Varadhachary, James L. Abbruzzese, Christopher H. Crane, Douglas B. Evans, and Peter W. T. Pisters. “Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy?J Am Coll Surg 204, no. 3 (March 2007): 347–55. https://doi.org/10.1016/j.jamcollsurg.2006.12.011.
Aloia TA, Lee JE, Vauthey J-N, Abdalla EK, Wolff RA, Varadhachary GR, et al. Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy? J Am Coll Surg. 2007 Mar;204(3):347–55.
Aloia, Thomas A., et al. “Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy?J Am Coll Surg, vol. 204, no. 3, Mar. 2007, pp. 347–55. Pubmed, doi:10.1016/j.jamcollsurg.2006.12.011.
Aloia TA, Lee JE, Vauthey J-N, Abdalla EK, Wolff RA, Varadhachary GR, Abbruzzese JL, Crane CH, Evans DB, Pisters PWT. Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy? J Am Coll Surg. 2007 Mar;204(3):347–355.
Journal cover image

Published In

J Am Coll Surg

DOI

ISSN

1072-7515

Publication Date

March 2007

Volume

204

Issue

3

Start / End Page

347 / 355

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Surgery
  • Risk Factors
  • Radiotherapy, Adjuvant
  • Prospective Studies
  • Pancreaticoduodenectomy
  • Pancreatic Neoplasms
  • Middle Aged
  • Male