Cisplatin, 5-fluorouracil, and leucovorin in the therapy of adenocarcinomas of the pancreas
Publication
, Journal Article
Jones, DV; Sugarman, SM; Markowitz, AB; Levin, B; Abbruzzese, JL; Evans, DB; Charnsangavej, C; Smith, R; Patt, YZ
Published in: Oncology Reports
January 1, 1995
Pancreatic cancer is resistant to most chemotherapeutic regimens. Based upon evidence of synergy between 5-fluorouracil (5-FU) and cisplatin (CDDP), and of enhanced 5-FU activity in the presence of leucovorin in other neoplasms, a phase II study of CDDP, 5-FU, and leucovorin was conducted to determine the efficacy of this regimen in patients with unresectable adenocarcinomas of the pancreas. Nineteen patients were enrolled, and all were evaluable for toxicity and response. One complete and two partial responses were observed (15.8%). Adverse effects were reversible and tolerable. This regimen has limited activity against pancreatic cancer, and cannot be recommended as standard therapy in this disease.
Duke Scholars
Published In
Oncology Reports
DOI
ISSN
1021-335X
Publication Date
January 1, 1995
Volume
2
Issue
6
Start / End Page
1121 / 1123
Related Subject Headings
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Jones, D. V., Sugarman, S. M., Markowitz, A. B., Levin, B., Abbruzzese, J. L., Evans, D. B., … Patt, Y. Z. (1995). Cisplatin, 5-fluorouracil, and leucovorin in the therapy of adenocarcinomas of the pancreas. Oncology Reports, 2(6), 1121–1123. https://doi.org/10.3892/or.2.6.1121
Jones, D. V., S. M. Sugarman, A. B. Markowitz, B. Levin, J. L. Abbruzzese, D. B. Evans, C. Charnsangavej, R. Smith, and Y. Z. Patt. “Cisplatin, 5-fluorouracil, and leucovorin in the therapy of adenocarcinomas of the pancreas.” Oncology Reports 2, no. 6 (January 1, 1995): 1121–23. https://doi.org/10.3892/or.2.6.1121.
Jones DV, Sugarman SM, Markowitz AB, Levin B, Abbruzzese JL, Evans DB, et al. Cisplatin, 5-fluorouracil, and leucovorin in the therapy of adenocarcinomas of the pancreas. Oncology Reports. 1995 Jan 1;2(6):1121–3.
Jones, D. V., et al. “Cisplatin, 5-fluorouracil, and leucovorin in the therapy of adenocarcinomas of the pancreas.” Oncology Reports, vol. 2, no. 6, Jan. 1995, pp. 1121–23. Scopus, doi:10.3892/or.2.6.1121.
Jones DV, Sugarman SM, Markowitz AB, Levin B, Abbruzzese JL, Evans DB, Charnsangavej C, Smith R, Patt YZ. Cisplatin, 5-fluorouracil, and leucovorin in the therapy of adenocarcinomas of the pancreas. Oncology Reports. 1995 Jan 1;2(6):1121–1123.
Published In
Oncology Reports
DOI
ISSN
1021-335X
Publication Date
January 1, 1995
Volume
2
Issue
6
Start / End Page
1121 / 1123
Related Subject Headings
- 1112 Oncology and Carcinogenesis