The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
Publication
, Journal Article
Jiao, L; Hassan, MM; Bondy, ML; Abbruzzese, JL; Evans, DB; Li, D
Published in: Cancer Lett
January 8, 2007
We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer.
Duke Scholars
Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
January 8, 2007
Volume
245
Issue
1-2
Start / End Page
61 / 68
Location
Ireland
Related Subject Headings
- Xeroderma Pigmentosum Group D Protein
- Smoking
- Risk Factors
- Polymorphism, Single Nucleotide
- Pancreatic Neoplasms
- Oncology & Carcinogenesis
- Middle Aged
- Male
- Lysine
- Linkage Disequilibrium
Citation
APA
Chicago
ICMJE
MLA
NLM
Jiao, L., Hassan, M. M., Bondy, M. L., Abbruzzese, J. L., Evans, D. B., & Li, D. (2007). The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. Cancer Lett, 245(1–2), 61–68. https://doi.org/10.1016/j.canlet.2005.12.026
Jiao, Li, Manal M. Hassan, Melissa L. Bondy, James L. Abbruzzese, Douglas B. Evans, and Donghui Li. “The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.” Cancer Lett 245, no. 1–2 (January 8, 2007): 61–68. https://doi.org/10.1016/j.canlet.2005.12.026.
Jiao L, Hassan MM, Bondy ML, Abbruzzese JL, Evans DB, Li D. The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. Cancer Lett. 2007 Jan 8;245(1–2):61–8.
Jiao, Li, et al. “The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.” Cancer Lett, vol. 245, no. 1–2, Jan. 2007, pp. 61–68. Pubmed, doi:10.1016/j.canlet.2005.12.026.
Jiao L, Hassan MM, Bondy ML, Abbruzzese JL, Evans DB, Li D. The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. Cancer Lett. 2007 Jan 8;245(1–2):61–68.
Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
January 8, 2007
Volume
245
Issue
1-2
Start / End Page
61 / 68
Location
Ireland
Related Subject Headings
- Xeroderma Pigmentosum Group D Protein
- Smoking
- Risk Factors
- Polymorphism, Single Nucleotide
- Pancreatic Neoplasms
- Oncology & Carcinogenesis
- Middle Aged
- Male
- Lysine
- Linkage Disequilibrium