Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release.
Publication
, Journal Article
Shakya, A; Dougherty, CA; Xue, Y; Al-Hashimi, HM; Banaszak Holl, MM
Published in: Biomacromolecules
January 11, 2016
A combination of solution NMR, dynamic light scattering (DLS), and fluorescence quenching assays were employed to obtain insights into the dynamics and structural features of a polyplex system consisting of HIV-1 transactivation response element (TAR) and PEGylated generation 5 poly(amidoamine) dendrimer (G5-PEG). NMR chemical shift mapping and (13)C spin relaxation based dynamics measurements depict the polyplex system as a highly dynamic assembly where the RNA, with its local structure and dynamics preserved, rapidly exchanges (
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Published In
Biomacromolecules
DOI
EISSN
1526-4602
Publication Date
January 11, 2016
Volume
17
Issue
1
Start / End Page
154 / 164
Location
United States
Related Subject Headings
- Transfection
- Response Elements
- RNA
- Polymers
- Polyethylene Glycols
- Polyamines
- Magnetic Resonance Spectroscopy
- HIV-1
- Dendrimers
- 40 Engineering
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ICMJE
MLA
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Shakya, A., Dougherty, C. A., Xue, Y., Al-Hashimi, H. M., & Banaszak Holl, M. M. (2016). Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. Biomacromolecules, 17(1), 154–164. https://doi.org/10.1021/acs.biomac.5b01280
Shakya, Anisha, Casey A. Dougherty, Yi Xue, Hashim M. Al-Hashimi, and Mark M. Banaszak Holl. “Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release.” Biomacromolecules 17, no. 1 (January 11, 2016): 154–64. https://doi.org/10.1021/acs.biomac.5b01280.
Shakya A, Dougherty CA, Xue Y, Al-Hashimi HM, Banaszak Holl MM. Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. Biomacromolecules. 2016 Jan 11;17(1):154–64.
Shakya, Anisha, et al. “Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release.” Biomacromolecules, vol. 17, no. 1, Jan. 2016, pp. 154–64. Pubmed, doi:10.1021/acs.biomac.5b01280.
Shakya A, Dougherty CA, Xue Y, Al-Hashimi HM, Banaszak Holl MM. Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. Biomacromolecules. 2016 Jan 11;17(1):154–164.
Published In
Biomacromolecules
DOI
EISSN
1526-4602
Publication Date
January 11, 2016
Volume
17
Issue
1
Start / End Page
154 / 164
Location
United States
Related Subject Headings
- Transfection
- Response Elements
- RNA
- Polymers
- Polyethylene Glycols
- Polyamines
- Magnetic Resonance Spectroscopy
- HIV-1
- Dendrimers
- 40 Engineering