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Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.

Publication ,  Journal Article
Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suárez-Roca, H
Published in: European journal of pharmacology
January 1999

Dynorphin A-(1-17) has been found to produce spinal antianalgesia and allodynia. Thus, we studied whether dynorphin A-(1-17) modulates substance P release evoked by the C-fiber-selective stimulant capsaicin (1 microM) from trigeminal nucleus caudalis slices. Very low concentrations of dynorphin A-(1-17) (0.01-0.1 nM) strongly facilitated capsaicin-evoked substance P release. This dynorphin A-(1-17) effect was not blocked by the opioid receptor antagonists naloxone (100 nM), beta-funaltrexamine (20 nM), naloxonazine (1 nM), nor-binaltorphimine (3 nM) and ICI 174,864 (N,N-dialyl-Tyr-Aib-Phe-Leu; 0.3 microM). Yet, the effect of dynorphin A-(1-17) was blocked by the NMDA receptor antagonist MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5-10-imine maleate; 0.3 microM). Neonatal treatment with capsaicin (50 mg/kg s.c.), which destroys substance P-containing primary afferents, abolished the excitatory effect of dynorphin A-(1-17) on K+-evoked substance P release. In conclusion, dynorphin A-(1-17) increases substance P release from C-fibers by the activation of NMDA receptors which supports the involvement of presynaptic mechanisms in dynorphin-induced antianalgesia and allodynia.

Duke Scholars

Published In

European journal of pharmacology

DOI

EISSN

1879-0712

ISSN

0014-2999

Publication Date

January 1999

Volume

366

Issue

1

Start / End Page

27 / 34

Related Subject Headings

  • Trigeminal Nuclei
  • Substance P
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Pharmacology & Pharmacy
  • Neurons, Afferent
  • Nerve Fibers
  • Narcotic Antagonists
  • Naltrexone
 

Citation

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ICMJE
MLA
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Arcaya, J. L., Cano, G., Gómez, G., Maixner, W., & Suárez-Roca, H. (1999). Dynorphin A increases substance P release from trigeminal primary afferent C-fibers. European Journal of Pharmacology, 366(1), 27–34. https://doi.org/10.1016/s0014-2999(98)00897-8
Arcaya, J. L., G. Cano, G. Gómez, W. Maixner, and H. Suárez-Roca. “Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.European Journal of Pharmacology 366, no. 1 (January 1999): 27–34. https://doi.org/10.1016/s0014-2999(98)00897-8.
Arcaya JL, Cano G, Gómez G, Maixner W, Suárez-Roca H. Dynorphin A increases substance P release from trigeminal primary afferent C-fibers. European journal of pharmacology. 1999 Jan;366(1):27–34.
Arcaya, J. L., et al. “Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.European Journal of Pharmacology, vol. 366, no. 1, Jan. 1999, pp. 27–34. Epmc, doi:10.1016/s0014-2999(98)00897-8.
Arcaya JL, Cano G, Gómez G, Maixner W, Suárez-Roca H. Dynorphin A increases substance P release from trigeminal primary afferent C-fibers. European journal of pharmacology. 1999 Jan;366(1):27–34.
Journal cover image

Published In

European journal of pharmacology

DOI

EISSN

1879-0712

ISSN

0014-2999

Publication Date

January 1999

Volume

366

Issue

1

Start / End Page

27 / 34

Related Subject Headings

  • Trigeminal Nuclei
  • Substance P
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Pharmacology & Pharmacy
  • Neurons, Afferent
  • Nerve Fibers
  • Narcotic Antagonists
  • Naltrexone