
Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers.
Publication
, Journal Article
Cano, G; Arcaya, JL; Gómez, G; Maixner, W; Suarez-Roca, H
Published in: Neurochemical research
October 1999
Morphine produces a multiphasic modulation of K+-evoked substance P release from trigeminal slices and dorsal root ganglion neurons in culture. We now found that the C-fiber stimulant, capsaicin (1 microM), evoked release of substance P that was inhibited, enhanced and inhibited by 0.1 nM, 1 microM, and 10 microM morphine, respectively. This morphine's multiphasic effect was blocked by naloxone (100 nM). Neonatal treatment with capsaicin produced thermal hypoalgesia and abolished the multiphasic effect of morphine on substance P release evoked by 50 mM K+. These findings suggest that the multiphasic modulation of substance P release by morphine is dependent on C-type afferents and may be of relevance to nociception.
Duke Scholars
Published In
Neurochemical research
DOI
EISSN
1573-6903
ISSN
0364-3190
Publication Date
October 1999
Volume
24
Issue
10
Start / End Page
1203 / 1207
Related Subject Headings
- Substance P
- Rats, Sprague-Dawley
- Rats
- Potassium
- Neurons, Afferent
- Neurology & Neurosurgery
- Nerve Fibers
- Morphine
- Male
- Capsaicin
Citation
APA
Chicago
ICMJE
MLA
NLM
Cano, G., Arcaya, J. L., Gómez, G., Maixner, W., & Suarez-Roca, H. (1999). Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers. Neurochemical Research, 24(10), 1203–1207. https://doi.org/10.1023/a:1020963120333
Cano, G., J. L. Arcaya, G. Gómez, W. Maixner, and H. Suarez-Roca. “Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers.” Neurochemical Research 24, no. 10 (October 1999): 1203–7. https://doi.org/10.1023/a:1020963120333.
Cano G, Arcaya JL, Gómez G, Maixner W, Suarez-Roca H. Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers. Neurochemical research. 1999 Oct;24(10):1203–7.
Cano, G., et al. “Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers.” Neurochemical Research, vol. 24, no. 10, Oct. 1999, pp. 1203–07. Epmc, doi:10.1023/a:1020963120333.
Cano G, Arcaya JL, Gómez G, Maixner W, Suarez-Roca H. Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers. Neurochemical research. 1999 Oct;24(10):1203–1207.

Published In
Neurochemical research
DOI
EISSN
1573-6903
ISSN
0364-3190
Publication Date
October 1999
Volume
24
Issue
10
Start / End Page
1203 / 1207
Related Subject Headings
- Substance P
- Rats, Sprague-Dawley
- Rats
- Potassium
- Neurons, Afferent
- Neurology & Neurosurgery
- Nerve Fibers
- Morphine
- Male
- Capsaicin