Evolution of Thermal Dosimetry for Application of Hyperthermia to Treat Cancer
The use of heat to treat cancer has been extensively studied in preclinical models and in human clinical trials. When combined with radiotherapy and chemotherapy, hyperthermia can yield synergistic interactions that increase likelihood that tumors will be controlled locally. Some evidence also exists that improvement in local tumor control. can lead to survival advantages. The achievement of therapeutic success with thermal therapies, however, requires a robust thermal dosimetry. This paper provides an overview of the evolution of thermometry and thermal dosimetry for both traditional hyperthermia and thermal ablation. Following the thermal dosimetry discussion, a brief review of key clinical trial results is discussed. © 2015 Elsevier Inc..
