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Genomewide search for type 2 diabetes susceptibility genes in four American populations.

Publication ,  Journal Article
Ehm, MG; Karnoub, MC; Sakul, H; Gottschalk, K; Holt, DC; Weber, JL; Vaske, D; Briley, D; Briley, L; Kopf, J; McMillen, P; Nguyen, Q; Lai, EH ...
Published in: Am J Hum Genet
June 2000

Type 2 diabetes is a serious, genetically influenced disease for which no fully effective treatments are available. Identification of biochemical or regulatory pathways involved in the disease syndrome could lead to innovative therapeutic interventions. One way to identify such pathways is the genetic analysis of families with multiple affected members where disease predisposing genes are likely to be segregating. We undertook a genomewide screen (389-395 microsatellite markers) in samples of 835 white, 591 Mexican American, 229 black, and 128 Japanese American individuals collected as part of the American Diabetes Association's GENNID study. Multipoint nonparametric linkage analyses were performed with diabetes, and diabetes or impaired glucose homeostasis (IH). Linkage to diabetes or IH was detected near markers D5S1404 (map position 77 cM, LOD = 2.80), D12S853 (map position 82 cM, LOD = 2.81) and GATA172D05 (X-chromosome map position 130 cM, LOD = 2.99) in whites, near marker D3S2432 (map position 51 cM, LOD = 3.91) in Mexican Americans, and near marker D10S1412 (map position 14 cM, LOD = 2.39) in African Americans mainly collected in phase 1 of the study. Further analyses showed evidence for interactions between the chromosome 5 locus and region on chromosome 12 containing the MODY 3 gene (map position 132 cM) and between the X-chromosome locus and region near D12S853 (map position 82 cM) in whites. Although these results were not replicated in samples collected in phase 2 of the GENNID study, the region on chromosome 12 was replicated in samples from whites described by Bektas et al. (1999).

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Published In

Am J Hum Genet

DOI

ISSN

0002-9297

Publication Date

June 2000

Volume

66

Issue

6

Start / End Page

1871 / 1881

Location

United States

Related Subject Headings

  • United States
  • Transcription Factors
  • Statistics, Nonparametric
  • Racial Groups
  • Pedigree
  • Nuclear Proteins
  • Middle Aged
  • Microsatellite Repeats
  • Mexico
  • Lod Score
 

Citation

APA
Chicago
ICMJE
MLA
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Ehm, M. G., Karnoub, M. C., Sakul, H., Gottschalk, K., Holt, D. C., Weber, J. L., … American Diabetes Association GENNID Study Group. Genetics of NIDDM, . (2000). Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am J Hum Genet, 66(6), 1871–1881. https://doi.org/10.1086/302950
Ehm, M. G., M. C. Karnoub, H. Sakul, K. Gottschalk, D. C. Holt, J. L. Weber, D. Vaske, et al. “Genomewide search for type 2 diabetes susceptibility genes in four American populations.Am J Hum Genet 66, no. 6 (June 2000): 1871–81. https://doi.org/10.1086/302950.
Ehm MG, Karnoub MC, Sakul H, Gottschalk K, Holt DC, Weber JL, et al. Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am J Hum Genet. 2000 Jun;66(6):1871–81.
Ehm, M. G., et al. “Genomewide search for type 2 diabetes susceptibility genes in four American populations.Am J Hum Genet, vol. 66, no. 6, June 2000, pp. 1871–81. Pubmed, doi:10.1086/302950.
Ehm MG, Karnoub MC, Sakul H, Gottschalk K, Holt DC, Weber JL, Vaske D, Briley D, Briley L, Kopf J, McMillen P, Nguyen Q, Reisman M, Lai EH, Joslyn G, Shepherd NS, Bell C, Wagner MJ, Burns DK, American Diabetes Association GENNID Study Group. Genetics of NIDDM. Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am J Hum Genet. 2000 Jun;66(6):1871–1881.
Journal cover image

Published In

Am J Hum Genet

DOI

ISSN

0002-9297

Publication Date

June 2000

Volume

66

Issue

6

Start / End Page

1871 / 1881

Location

United States

Related Subject Headings

  • United States
  • Transcription Factors
  • Statistics, Nonparametric
  • Racial Groups
  • Pedigree
  • Nuclear Proteins
  • Middle Aged
  • Microsatellite Repeats
  • Mexico
  • Lod Score