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The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153.

Publication ,  Journal Article
Liu, J; Prunuske, AJ; Fager, AM; Ullman, KS
Published in: Dev Cell
September 2003

Nuclear envelope breakdown is a critical step in the cell cycle of higher eukaryotes. Although integral membrane proteins associated with the nuclear membrane have been observed to disperse into the endoplasmic reticulum at mitosis, the mechanisms involved in this reorganization remain to be fully elucidated. Here, using Xenopus extracts, we report a role for the COPI coatomer complex in nuclear envelope breakdown, implicating vesiculation as an important step. We have found that a nuclear pore protein, Nup153, plays a critical role in directing COPI to the nuclear membrane at mitosis and that this event provides feedback to other aspects of nuclear disassembly. These results provide insight into how key steps in nuclear division are orchestrated.

Duke Scholars

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Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

September 2003

Volume

5

Issue

3

Start / End Page

487 / 498

Location

United States

Related Subject Headings

  • Zinc Fingers
  • Xenopus
  • Silver Staining
  • Recombinant Proteins
  • Precipitin Tests
  • Peptide Fragments
  • Ovum
  • Nuclear Pore Complex Proteins
  • Nuclear Envelope
  • Microscopy, Confocal
 

Citation

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Chicago
ICMJE
MLA
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Liu, J., Prunuske, A. J., Fager, A. M., & Ullman, K. S. (2003). The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. Dev Cell, 5(3), 487–498. https://doi.org/10.1016/s1534-5807(03)00262-4
Liu, Jin, Amy J. Prunuske, Ammon M. Fager, and Katharine S. Ullman. “The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153.Dev Cell 5, no. 3 (September 2003): 487–98. https://doi.org/10.1016/s1534-5807(03)00262-4.
Liu J, Prunuske AJ, Fager AM, Ullman KS. The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. Dev Cell. 2003 Sep;5(3):487–98.
Liu, Jin, et al. “The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153.Dev Cell, vol. 5, no. 3, Sept. 2003, pp. 487–98. Pubmed, doi:10.1016/s1534-5807(03)00262-4.
Liu J, Prunuske AJ, Fager AM, Ullman KS. The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. Dev Cell. 2003 Sep;5(3):487–498.
Journal cover image

Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

September 2003

Volume

5

Issue

3

Start / End Page

487 / 498

Location

United States

Related Subject Headings

  • Zinc Fingers
  • Xenopus
  • Silver Staining
  • Recombinant Proteins
  • Precipitin Tests
  • Peptide Fragments
  • Ovum
  • Nuclear Pore Complex Proteins
  • Nuclear Envelope
  • Microscopy, Confocal