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Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development.

Publication ,  Journal Article
Fedoriw, Y; Samulski, TD; Deal, AM; Dunphy, CH; Sharf, A; Shea, TC; Serody, JS; Sarantopoulos, S
Published in: Biol Blood Marrow Transplant
June 2012

Patients without chronic graft-versus-host disease (cGVHD) have robust B cell reconstitution and are able to maintain B cell homeostasis after allogeneic hematopoietic stem cell transplantation (HSCT). To determine whether B lymphopoiesis differs before cGVHD develops, we examined bone marrow (BM) biopsies for terminal deoxynucleotidyl transferase (TdT) and PAX5 immunostaining early post-HSCT at day 30 when all patients have been shown to have high B cell activating factor (BAFF) levels. We found significantly greater numbers of BM B cell precursors in patients who did not develop cGVHD compared with those who developed cGVHD (median = 44 vs 2 cells/high powered field [hpf]; respectively; P < .001). Importantly, a significant increase in precursor B cells was maintained when patients receiving high-dose steroid therapy were excluded (median = 49 vs 20 cells/hpf; P = .017). Thus, we demonstrate the association of BM B cell production capacity in human GVHD development. Increased BM precursor B cell number may serve to predict good clinical outcome after HSCT.

Duke Scholars

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

June 2012

Volume

18

Issue

6

Start / End Page

968 / 973

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Conditioning
  • Steroids
  • Stem Cell Transplantation
  • Precursor Cells, B-Lymphoid
  • PAX5 Transcription Factor
  • Middle Aged
  • Male
  • Lymphopoiesis
  • Lymphocyte Count
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fedoriw, Y., Samulski, T. D., Deal, A. M., Dunphy, C. H., Sharf, A., Shea, T. C., … Sarantopoulos, S. (2012). Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development. Biol Blood Marrow Transplant, 18(6), 968–973. https://doi.org/10.1016/j.bbmt.2012.03.005
Fedoriw, Yuri, T Danielle Samulski, Allison M. Deal, Cherie H. Dunphy, Andrew Sharf, Thomas C. Shea, Jonathan S. Serody, and Stefanie Sarantopoulos. “Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development.Biol Blood Marrow Transplant 18, no. 6 (June 2012): 968–73. https://doi.org/10.1016/j.bbmt.2012.03.005.
Fedoriw Y, Samulski TD, Deal AM, Dunphy CH, Sharf A, Shea TC, et al. Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development. Biol Blood Marrow Transplant. 2012 Jun;18(6):968–73.
Fedoriw, Yuri, et al. “Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development.Biol Blood Marrow Transplant, vol. 18, no. 6, June 2012, pp. 968–73. Pubmed, doi:10.1016/j.bbmt.2012.03.005.
Fedoriw Y, Samulski TD, Deal AM, Dunphy CH, Sharf A, Shea TC, Serody JS, Sarantopoulos S. Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development. Biol Blood Marrow Transplant. 2012 Jun;18(6):968–973.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

June 2012

Volume

18

Issue

6

Start / End Page

968 / 973

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Conditioning
  • Steroids
  • Stem Cell Transplantation
  • Precursor Cells, B-Lymphoid
  • PAX5 Transcription Factor
  • Middle Aged
  • Male
  • Lymphopoiesis
  • Lymphocyte Count