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IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.

Publication ,  Journal Article
Wallet, MA; Wallet, SM; Guiulfo, G; Sleasman, JW; Goodenow, MM
Published in: Cell Immunol
2010

The objective was to assess outcomes of IFNgamma-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Human macrophages primed by IFNgamma and activated by HMW-HA were evaluated for cytokine secretion by ELISA and Milliplex assay and activation profiles by nuclear transcription factor EIA. IFNgamma-primed, HMW-HA-activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFNgamma suppressed HMW-HA-induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun. IFNgamma modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion.

Duke Scholars

Published In

Cell Immunol

DOI

EISSN

1090-2163

Publication Date

2010

Volume

262

Issue

2

Start / End Page

84 / 88

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Molecular Weight
  • Macrophages
  • Macrophage Activation
  • Joints
  • Interferon-gamma
  • Inflammation
  • Immunology
  • Hyaluronic Acid
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wallet, M. A., Wallet, S. M., Guiulfo, G., Sleasman, J. W., & Goodenow, M. M. (2010). IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. Cell Immunol, 262(2), 84–88. https://doi.org/10.1016/j.cellimm.2010.02.013
Wallet, Mark A., Shannon M. Wallet, Giorgio Guiulfo, John W. Sleasman, and Maureen M. Goodenow. “IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.Cell Immunol 262, no. 2 (2010): 84–88. https://doi.org/10.1016/j.cellimm.2010.02.013.
Wallet MA, Wallet SM, Guiulfo G, Sleasman JW, Goodenow MM. IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. Cell Immunol. 2010;262(2):84–8.
Wallet, Mark A., et al. “IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.Cell Immunol, vol. 262, no. 2, 2010, pp. 84–88. Pubmed, doi:10.1016/j.cellimm.2010.02.013.
Wallet MA, Wallet SM, Guiulfo G, Sleasman JW, Goodenow MM. IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. Cell Immunol. 2010;262(2):84–88.
Journal cover image

Published In

Cell Immunol

DOI

EISSN

1090-2163

Publication Date

2010

Volume

262

Issue

2

Start / End Page

84 / 88

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Molecular Weight
  • Macrophages
  • Macrophage Activation
  • Joints
  • Interferon-gamma
  • Inflammation
  • Immunology
  • Hyaluronic Acid
  • Humans