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Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults.

Publication ,  Journal Article
Shah, K; Stufflebam, A; Hilton, TN; Sinacore, DR; Klein, S; Villareal, DT
Published in: Obesity (Silver Spring)
December 2009

Both obesity and aging increase intrahepatic fat (IHF) content, which leads to nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities such as insulin resistance. We evaluated the effects of diet and diet in conjunction with exercise on IHF content and associated metabolic abnormalities in obese older adults. Eighteen obese (BMI >or=30 kg/m(2)) older (>or=65 years old) adults completed a 6-month clinical trial. Participants were randomized to diet (D group; n = 9) or diet + exercise (D+E group; n = 9). Primary outcome was IHF quantified by magnetic resonance spectroscopy (MRS). Secondary outcomes included insulin sensitivity (assessed by oral glucose tolerance), body composition (assessed by dual-energy X-ray absorptiometry), physical function (VO(2 peak) and strength), glucose, lipids, and blood pressure (BP). Body weight (D: -9 +/- 1%, D+E: -10 +/- 2%, both P < 0.05) and fat mass (D: -13 +/- 3%, D+E -16 +/- 3%, both P < 0.05) decreased in both groups but there was no difference between groups. IHF decreased to a similar extent in both groups (D: -46 +/- 11%, D+E: -45 +/- 8%, both P < 0.05), which was accompanied by comparable improvements in insulin sensitivity (D: 66 +/- 25%, D+E: 68 +/- 28%, both P < 0.05). The relative decreases in IHF correlated directly with relative increases in insulin sensitivity index (ISI) (r = -0.52; P < 0.05). Improvements in VO(2 peak), strength, plasma triglyceride (TG), and low-density lipoprotein-cholesterol concentration, and diastolic BP occurred in the D+E group (all P < 0.05) but not in the D group. Diet with or without exercise results in significant decreases in IHF content accompanied by considerable improvements in insulin sensitivity in obese older adults. The addition of exercise to diet therapy improves physical function and other obesity- and aging-related metabolic abnormalities.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

December 2009

Volume

17

Issue

12

Start / End Page

2162 / 2168

Location

United States

Related Subject Headings

  • Triglycerides
  • Treatment Outcome
  • Physical Fitness
  • Oxygen Consumption
  • Obesity
  • Male
  • Insulin Resistance
  • Humans
  • Glucose Intolerance
  • Female
 

Citation

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Shah, K., Stufflebam, A., Hilton, T. N., Sinacore, D. R., Klein, S., & Villareal, D. T. (2009). Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring), 17(12), 2162–2168. https://doi.org/10.1038/oby.2009.126
Shah, Krupa, Abby Stufflebam, Tiffany N. Hilton, David R. Sinacore, Samuel Klein, and Dennis T. Villareal. “Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults.Obesity (Silver Spring) 17, no. 12 (December 2009): 2162–68. https://doi.org/10.1038/oby.2009.126.
Shah K, Stufflebam A, Hilton TN, Sinacore DR, Klein S, Villareal DT. Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring). 2009 Dec;17(12):2162–8.
Shah, Krupa, et al. “Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults.Obesity (Silver Spring), vol. 17, no. 12, Dec. 2009, pp. 2162–68. Pubmed, doi:10.1038/oby.2009.126.
Shah K, Stufflebam A, Hilton TN, Sinacore DR, Klein S, Villareal DT. Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring). 2009 Dec;17(12):2162–2168.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

December 2009

Volume

17

Issue

12

Start / End Page

2162 / 2168

Location

United States

Related Subject Headings

  • Triglycerides
  • Treatment Outcome
  • Physical Fitness
  • Oxygen Consumption
  • Obesity
  • Male
  • Insulin Resistance
  • Humans
  • Glucose Intolerance
  • Female