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Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations

Publication ,  Journal Article
Randles, A; Draeger, E; Michor, F
Published in: Computing in Cardiology
January 1, 2014

Coarctation of the aorta (CoA) is one of the most common congenital heart defects in the United States, and despite treatment, patients have a decrease in life expectancy. Computational fluid dynamics simulations can provide the physician with a non-invasive method to measure the pressure gradient. With HARVEY, a massively parallel hemodynamics application, patient specific simulations can be conducted of large regions of the vasculature. The pressure across the stenosis is impacted by flow from nearby vessels. The purpose of this study was to study the impact of including these distal vessels in the simulation on the resulting pressure measurements. Computational fluid dynamic simulations were conducted in three subsets of one patient's vasculature. We demonstrate up to a 29% difference in calculated pressure gradient based on the number of vessels included in the simulation. These initial results are positive but need to be substantiated with further patient studies.

Duke Scholars

Published In

Computing in Cardiology

EISSN

2325-887X

ISSN

2325-8861

Publication Date

January 1, 2014

Volume

41

Issue

January

Start / End Page

217 / 220
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Randles, A., Draeger, E., & Michor, F. (2014). Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations. Computing in Cardiology, 41(January), 217–220.
Randles, A., E. Draeger, and F. Michor. “Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations.” Computing in Cardiology 41, no. January (January 1, 2014): 217–20.
Randles A, Draeger E, Michor F. Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations. Computing in Cardiology. 2014 Jan 1;41(January):217–20.
Randles, A., et al. “Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations.” Computing in Cardiology, vol. 41, no. January, Jan. 2014, pp. 217–20.
Randles A, Draeger E, Michor F. Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations. Computing in Cardiology. 2014 Jan 1;41(January):217–220.

Published In

Computing in Cardiology

EISSN

2325-887X

ISSN

2325-8861

Publication Date

January 1, 2014

Volume

41

Issue

January

Start / End Page

217 / 220