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Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure.

Publication ,  Journal Article
Moe, GW; Stopps, TP; Angus, C; Forster, C; De Bold, AJ; Armstrong, PW
Published in: J Am Coll Cardiol
January 1989

The pathophysiologic role of atrial natriuretic factor and other neuroendocrine variables in relation to serum sodium and renal function was evaluated in 15 conscious dogs with severe chronic ventricular pacing-induced heart failure (250 beats/min for 5.1 +/- 0.4 weeks). Six sham-operated dogs observed over an 8 week period served as controls. Development of heart failure was characterized by a progressive increase in plasma norepinephrine, renin activity and aldosterone from control values of 293 +/- 15 pg/ml, 1.4 +/- 0.4 ng/ml per h and 124 +/- 42 pg/ml, respectively, to 1,066 +/- 96 pg/ml, 10.2 +/- 2.4 ng/ml per h and 577 +/- 151 pg/ml (all p less than 0.01), respectively, at severe heart failure. In contrast to other neuroendocrine variables, plasma atrial natriuretic factor increased from a control level of 243 +/- 74 pg/ml to a peak concentration of 724 +/- 149 pg/ml (p less than 0.01) at 2 weeks, then declined and plateaued at twice the level of the control value as severe heart failure developed. At severe heart failure, serum sodium decreased from 147 +/- 0.6 to 141.8 +/- 2.1 mmol/liter (p less than 0.05), whereas urea increased from 6.0 +/- 0.5 to 7.8 +/- 0.6 mmol/liter (p less than 0.05). The change in serum sodium concentration correlated with plasma renin activity and aldosterone (r = -0.77, -0.88, respectively, both p less than 0.01), but not with norepinephrine or atrial natriuretic factor. When sinus rhythm was restored, 14 dogs were observed for 48 to 72 h and 8 dogs were followed up for another 4 weeks after cessation of pacing.(ABSTRACT TRUNCATED AT 250 WORDS)

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Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

January 1989

Volume

13

Issue

1

Start / End Page

173 / 179

Location

United States

Related Subject Headings

  • Sodium
  • Neurosecretory Systems
  • Male
  • Kidney
  • Heart Failure
  • Electrolytes
  • Dogs
  • Cardiovascular System & Hematology
  • Cardiac Pacing, Artificial
  • Atrial Natriuretic Factor
 

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Moe, G. W., Stopps, T. P., Angus, C., Forster, C., De Bold, A. J., & Armstrong, P. W. (1989). Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure. J Am Coll Cardiol, 13(1), 173–179. https://doi.org/10.1016/0735-1097(89)90567-6
Moe, G. W., T. P. Stopps, C. Angus, C. Forster, A. J. De Bold, and P. W. Armstrong. “Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure.J Am Coll Cardiol 13, no. 1 (January 1989): 173–79. https://doi.org/10.1016/0735-1097(89)90567-6.
Moe GW, Stopps TP, Angus C, Forster C, De Bold AJ, Armstrong PW. Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure. J Am Coll Cardiol. 1989 Jan;13(1):173–9.
Moe, G. W., et al. “Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure.J Am Coll Cardiol, vol. 13, no. 1, Jan. 1989, pp. 173–79. Pubmed, doi:10.1016/0735-1097(89)90567-6.
Moe GW, Stopps TP, Angus C, Forster C, De Bold AJ, Armstrong PW. Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure. J Am Coll Cardiol. 1989 Jan;13(1):173–179.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

January 1989

Volume

13

Issue

1

Start / End Page

173 / 179

Location

United States

Related Subject Headings

  • Sodium
  • Neurosecretory Systems
  • Male
  • Kidney
  • Heart Failure
  • Electrolytes
  • Dogs
  • Cardiovascular System & Hematology
  • Cardiac Pacing, Artificial
  • Atrial Natriuretic Factor