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The spectrum of unstable angina: prognostic role of serum creatine kinase determination.

Publication ,  Journal Article
Armstrong, PW; Chiong, MA; Parker, JO
Published in: Am J Cardiol
June 1982

A prospective study of 199 patients with unstable angina pectoris was undertaken to assess whether frequent serial sampling of serum creatine kinase (CK) was useful in predicting prognosis. Nineteen percent of the patients had transient CK elevations suggestive of a small myocardial infarct that was outside the detective ability of conventional electrocardiographic and enzymatic determinations. These patients had a 1 year mortality rate of 16 percent, which was significantly higher than that in the remaining patients (Fisher's exact test p = 0.05). Furthermore, the recurrence rate of myocardial infarction (14 percent) in the patients who had transient CK elevation was significantly greater than that (2 percent) in those who did not have CK elevation (Fisher's exact test p = 0/01). These data suggest that frequent serum CK sampling in the first 48 hours after admission for unstable angina has prognostic value and that persons with CK elevation may warrant a more aggressive approach to investigation and management.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

June 1982

Volume

49

Issue

8

Start / End Page

1849 / 1852

Location

United States

Related Subject Headings

  • Risk
  • Prospective Studies
  • Prognosis
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Female
  • Creatine Kinase
  • Cardiovascular System & Hematology
 

Citation

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Armstrong, P. W., Chiong, M. A., & Parker, J. O. (1982). The spectrum of unstable angina: prognostic role of serum creatine kinase determination. Am J Cardiol, 49(8), 1849–1852. https://doi.org/10.1016/0002-9149(82)90201-6
Armstrong, P. W., M. A. Chiong, and J. O. Parker. “The spectrum of unstable angina: prognostic role of serum creatine kinase determination.Am J Cardiol 49, no. 8 (June 1982): 1849–52. https://doi.org/10.1016/0002-9149(82)90201-6.
Armstrong PW, Chiong MA, Parker JO. The spectrum of unstable angina: prognostic role of serum creatine kinase determination. Am J Cardiol. 1982 Jun;49(8):1849–52.
Armstrong, P. W., et al. “The spectrum of unstable angina: prognostic role of serum creatine kinase determination.Am J Cardiol, vol. 49, no. 8, June 1982, pp. 1849–52. Pubmed, doi:10.1016/0002-9149(82)90201-6.
Armstrong PW, Chiong MA, Parker JO. The spectrum of unstable angina: prognostic role of serum creatine kinase determination. Am J Cardiol. 1982 Jun;49(8):1849–1852.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

June 1982

Volume

49

Issue

8

Start / End Page

1849 / 1852

Location

United States

Related Subject Headings

  • Risk
  • Prospective Studies
  • Prognosis
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Female
  • Creatine Kinase
  • Cardiovascular System & Hematology