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Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative.

Publication ,  Journal Article
Gill, S; Majumdar, S; Brown, NE; Armstrong, PW
Published in: Can J Cardiol
October 1997

Ticlopidine is an antiplatelet agent that has been proven efficacious in preventing vascular events in patients with a history of vasculopathy. Neutropenia is a significant adverse effect and pancytopenia is rarely reported. A fatal case of pancytopenia associated with unmonitored use of ticlopidine is presented. A 59-year-old woman presented with severe pneumonia and profound neutropenia (absolute neutrophil count 0%). She deteriorated with development of acute respiratory distress syndrome and a marked reduction in trilineage hematopoiesis. Despite prompt marrow response to granulocyte macrophage colony-stimulating factor (GM-CSF) and cessation of ticlopidine, appropriate antibiotics and other supportive therapy, she died 17 days after admission. Hematological monitoring is imperative to identify potential complications: if discovered late, there may be a role for GM-CSF for marrow support. Ticlopidine is indicated for patients intolerant of or nonresponsive to acetylsalicylic acid therapy. As the use of ticlopidine increases, clinicians must be aware of potential life-threatening complications associated with its use and monitor appropriately.

Duke Scholars

Published In

Can J Cardiol

ISSN

0828-282X

Publication Date

October 1997

Volume

13

Issue

10

Start / End Page

909 / 913

Location

England

Related Subject Headings

  • Ticlopidine
  • Respiratory Distress Syndrome
  • Pneumonia
  • Platelet Aggregation Inhibitors
  • Pancytopenia
  • Neutropenia
  • Middle Aged
  • Humans
  • Female
  • Fatal Outcome
 

Citation

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Gill, S., Majumdar, S., Brown, N. E., & Armstrong, P. W. (1997). Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative. Can J Cardiol, 13(10), 909–913.
Gill, S., S. Majumdar, N. E. Brown, and P. W. Armstrong. “Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative.Can J Cardiol 13, no. 10 (October 1997): 909–13.
Gill S, Majumdar S, Brown NE, Armstrong PW. Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative. Can J Cardiol. 1997 Oct;13(10):909–13.
Gill, S., et al. “Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative.Can J Cardiol, vol. 13, no. 10, Oct. 1997, pp. 909–13.
Gill S, Majumdar S, Brown NE, Armstrong PW. Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative. Can J Cardiol. 1997 Oct;13(10):909–913.
Journal cover image

Published In

Can J Cardiol

ISSN

0828-282X

Publication Date

October 1997

Volume

13

Issue

10

Start / End Page

909 / 913

Location

England

Related Subject Headings

  • Ticlopidine
  • Respiratory Distress Syndrome
  • Pneumonia
  • Platelet Aggregation Inhibitors
  • Pancytopenia
  • Neutropenia
  • Middle Aged
  • Humans
  • Female
  • Fatal Outcome