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Influence of skin site on bioavailability of nitroglycerin ointment in congestive heart failure.

Publication ,  Journal Article
Moe, G; Armstrong, PW
Published in: Am J Med
November 1986

Nitroglycerin ointment (12.5 to 50 mg) was administered in randomized fashion to three skin sites, arm, chest, or thigh, to compare the hemodynamic effects and bioavailability in nine patients with severe congestive heart failure. Hemodynamic parameters and arterial nitroglycerin concentrations were measured frequently for 12 hours after each application and for 90 minutes after removal of the ointment. During the study, left ventricular filling pressures decreased from control values of 25.0 +/- 8.6 mm Hg (arm), 25.7 +/- 10.9 mm Hg (chest), and 23.7 +/- 8.4 mm Hg (thigh) to 20.4 +/- 8.6 mm Hg, 20.4 +/- 8.5 mm Hg, and 20.0 +/- 7.5 mm Hg; p less than 0.05, less than 0.01, and difference not significant respectively. Peak nitroglycerin concentrations were 5.1 +/- 4.3 ng/ml (arm), 6.2 +/- 6.0 ng/ml (chest), and 4.1 +/- 6.3 ng/ml (thigh). No significant difference was observed in mean arterial pressure, left ventricular filling pressure, right atrial pressure, or nitroglycerin concentration among the sites. These data show that nitroglycerin ointment has similar bioavailability on the arm, chest, or thigh and therefore can be used interchangeably on these skin sites.

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Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

November 1986

Volume

81

Issue

5

Start / End Page

765 / 770

Location

United States

Related Subject Headings

  • Thorax
  • Thigh
  • Skin Absorption
  • Ointments
  • Nitroglycerin
  • Middle Aged
  • Male
  • Infusions, Intravenous
  • Humans
  • Heart Failure
 

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Moe, G., & Armstrong, P. W. (1986). Influence of skin site on bioavailability of nitroglycerin ointment in congestive heart failure. Am J Med, 81(5), 765–770. https://doi.org/10.1016/0002-9343(86)90341-4
Moe, G., and P. W. Armstrong. “Influence of skin site on bioavailability of nitroglycerin ointment in congestive heart failure.Am J Med 81, no. 5 (November 1986): 765–70. https://doi.org/10.1016/0002-9343(86)90341-4.
Moe, G., and P. W. Armstrong. “Influence of skin site on bioavailability of nitroglycerin ointment in congestive heart failure.Am J Med, vol. 81, no. 5, Nov. 1986, pp. 765–70. Pubmed, doi:10.1016/0002-9343(86)90341-4.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

November 1986

Volume

81

Issue

5

Start / End Page

765 / 770

Location

United States

Related Subject Headings

  • Thorax
  • Thigh
  • Skin Absorption
  • Ointments
  • Nitroglycerin
  • Middle Aged
  • Male
  • Infusions, Intravenous
  • Humans
  • Heart Failure