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Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog.

Publication ,  Journal Article
Forster, C; Naik, G; Armstrong, PW
Published in: Can J Physiol Pharmacol
January 1994

We have modified an assay utilizing ion-pair high-performance liquid chromatography with electrochemical detection to measure dihydroxyphenylalanine and dyhydroxyphenylglycol simultaneously with noradrenaline. We measured these agents at control, 1 and 3 weeks following the onset of rapid ventricular pacing, as well as 4 weeks after the cessation of a 3-week period of pacing. Our findings were as follows. Plasma noradrenaline increased significantly at 1 week and increased further after 3 weeks of pacing (control, 202 +/- 16; 1 week, 528 +/- 62; 3 weeks, 750 +/- 139 pg.mL-1). Plasma dihydroxyphenylalanine did not change throughout, while plasma dihydroxyphenylglycol was significantly elevated at 3 weeks (513 +/- 48 vs. 388 +/- 35 pg.mL-1 for the control). Four weeks after discontinuation of pacing, all parameters did not differ from the control. These results imply that during the development of heart failure, the rise in circulating noradrenaline does not reflect simply an increase in catecholamine synthesis, but that there are more dynamic changes associated with noradrenaline spill-over, uptake, and metabolism.

Duke Scholars

Published In

Can J Physiol Pharmacol

DOI

ISSN

0008-4212

Publication Date

January 1994

Volume

72

Issue

1

Start / End Page

45 / 49

Location

Canada

Related Subject Headings

  • Resorcinols
  • Physiology
  • Norepinephrine
  • Myocardium
  • Male
  • Heart Ventricles
  • Glycine
  • Electrochemistry
  • Dogs
  • Dihydroxyphenylalanine
 

Citation

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Forster, C., Naik, G., & Armstrong, P. W. (1994). Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog. Can J Physiol Pharmacol, 72(1), 45–49. https://doi.org/10.1139/y94-008
Forster, C., G. Naik, and P. W. Armstrong. “Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog.Can J Physiol Pharmacol 72, no. 1 (January 1994): 45–49. https://doi.org/10.1139/y94-008.
Forster C, Naik G, Armstrong PW. Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog. Can J Physiol Pharmacol. 1994 Jan;72(1):45–9.
Forster, C., et al. “Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog.Can J Physiol Pharmacol, vol. 72, no. 1, Jan. 1994, pp. 45–49. Pubmed, doi:10.1139/y94-008.
Forster C, Naik G, Armstrong PW. Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog. Can J Physiol Pharmacol. 1994 Jan;72(1):45–49.

Published In

Can J Physiol Pharmacol

DOI

ISSN

0008-4212

Publication Date

January 1994

Volume

72

Issue

1

Start / End Page

45 / 49

Location

Canada

Related Subject Headings

  • Resorcinols
  • Physiology
  • Norepinephrine
  • Myocardium
  • Male
  • Heart Ventricles
  • Glycine
  • Electrochemistry
  • Dogs
  • Dihydroxyphenylalanine