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Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein.

Publication ,  Journal Article
Polizzi, NF; Eibling, MJ; Perez-Aguilar, JM; Rawson, J; Lanci, CJ; Fry, HC; Beratan, DN; Saven, JG; Therien, MJ
Published in: Journal of the American Chemical Society
February 2016

We provide a direct measure of the change in effective dielectric constant (ε(S)) within a protein matrix after a photoinduced electron transfer (ET) reaction. A linked donor-bridge-acceptor molecule, PZn-Ph-NDI, consisting of a (porphinato)Zn donor (PZn), a phenyl bridge (Ph), and a naphthalene diimide acceptor (NDI), is shown to be a "meter" to indicate protein dielectric environment. We calibrated PZn-Ph-NDI ET dynamics as a function of solvent dielectric, and computationally de novo designed a protein SCPZnI3 to bind PZn-Ph-NDI in its interior. Mapping the protein ET dynamics onto the calibrated ET catalogue shows that SCPZnI3 undergoes a switch in the effective dielectric constant following photoinduced ET, from ε(S) ≈ 8 to ε(S) ≈ 3.

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Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2016

Volume

138

Issue

7

Start / End Page

2130 / 2133

Related Subject Headings

  • Zinc
  • Proteins
  • Photochemical Processes
  • Organometallic Compounds
  • Naphthalenes
  • Molecular Structure
  • Models, Molecular
  • Imides
  • General Chemistry
  • Electron Transport
 

Citation

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Polizzi, N. F., Eibling, M. J., Perez-Aguilar, J. M., Rawson, J., Lanci, C. J., Fry, H. C., … Therien, M. J. (2016). Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. Journal of the American Chemical Society, 138(7), 2130–2133. https://doi.org/10.1021/jacs.5b13180
Polizzi, Nicholas F., Matthew J. Eibling, Jose Manuel Perez-Aguilar, Jeff Rawson, Christopher J. Lanci, H Christopher Fry, David N. Beratan, Jeffery G. Saven, and Michael J. Therien. “Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein.Journal of the American Chemical Society 138, no. 7 (February 2016): 2130–33. https://doi.org/10.1021/jacs.5b13180.
Polizzi NF, Eibling MJ, Perez-Aguilar JM, Rawson J, Lanci CJ, Fry HC, et al. Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. Journal of the American Chemical Society. 2016 Feb;138(7):2130–3.
Polizzi, Nicholas F., et al. “Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein.Journal of the American Chemical Society, vol. 138, no. 7, Feb. 2016, pp. 2130–33. Epmc, doi:10.1021/jacs.5b13180.
Polizzi NF, Eibling MJ, Perez-Aguilar JM, Rawson J, Lanci CJ, Fry HC, Beratan DN, Saven JG, Therien MJ. Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein. Journal of the American Chemical Society. 2016 Feb;138(7):2130–2133.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2016

Volume

138

Issue

7

Start / End Page

2130 / 2133

Related Subject Headings

  • Zinc
  • Proteins
  • Photochemical Processes
  • Organometallic Compounds
  • Naphthalenes
  • Molecular Structure
  • Models, Molecular
  • Imides
  • General Chemistry
  • Electron Transport