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Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project.

Publication ,  Journal Article
Postema, AW; De Reijke, TM; Ukimura, O; Van den Bos, W; Azzouzi, AR; Barret, E; Baumunk, D; Blana, A; Bossi, A; Brausi, M; Coleman, JA ...
Published in: World J Urol
October 2016

PURPOSE: To reach standardized terminology in focal therapy (FT) for prostate cancer (PCa). METHODS: A four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT was collected from the panel by three rounds of online questionnaires. During a face-to-face meeting on June 21, 2015, attended by 38 experts, all data from the online rounds were reviewed and recommendations for definitions were formulated. RESULTS: Consensus was attained on 23 of 27 topics; Targeted FT was defined as a lesion-based treatment strategy, treating all identified significant cancer foci; FT was generically defined as an anatomy-based (zonal) treatment strategy. Treatment failure due to the ablative energy inadequately destroying treated tissue is defined as ablation failure. In targeting failure the energy is not adequately applied to the tumor spatially and selection failure occurs when a patient was wrongfully selected for FT. No definition of biochemical recurrence can be recommended based on the current data. Important definitions for outcome measures are potency (minimum IIEF-5 score of 21), incontinence (new need for pads or leakage) and deterioration in urinary function (increase in IPSS >5 points). No agreement on the best quality of life tool was established, but UCLA-EPIC and EORTC-QLQ-30 were most commonly supported by the experts. A complete overview of statements is presented in the text. CONCLUSION: Focal therapy is an emerging field of PCa therapeutics. Standardization of definitions helps to create comparable research results and facilitate clear communication in clinical practice.

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Published In

World J Urol

DOI

EISSN

1433-8726

Publication Date

October 2016

Volume

34

Issue

10

Start / End Page

1373 / 1382

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Surveys and Questionnaires
  • Quality of Life
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Male
  • Humans
  • Delphi Technique
  • Consensus
  • Combined Modality Therapy
 

Citation

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Postema, A. W., De Reijke, T. M., Ukimura, O., Van den Bos, W., Azzouzi, A. R., Barret, E., … De la Rosette, J. J. (2016). Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project. World J Urol, 34(10), 1373–1382. https://doi.org/10.1007/s00345-016-1782-x
Postema, A. W., T. M. De Reijke, O. Ukimura, W. Van den Bos, A. R. Azzouzi, E. Barret, D. Baumunk, et al. “Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project.World J Urol 34, no. 10 (October 2016): 1373–82. https://doi.org/10.1007/s00345-016-1782-x.
Postema AW, De Reijke TM, Ukimura O, Van den Bos W, Azzouzi AR, Barret E, et al. Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project. World J Urol. 2016 Oct;34(10):1373–82.
Postema, A. W., et al. “Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project.World J Urol, vol. 34, no. 10, Oct. 2016, pp. 1373–82. Pubmed, doi:10.1007/s00345-016-1782-x.
Postema AW, De Reijke TM, Ukimura O, Van den Bos W, Azzouzi AR, Barret E, Baumunk D, Blana A, Bossi A, Brausi M, Coleman JA, Crouzet S, Dominguez-Escrig J, Eggener S, Ganzer R, Ghai S, Gill IS, Gupta RT, Henkel TO, Hohenfellner M, Jones JS, Kahmann F, Kastner C, Köhrmann KU, Kovacs G, Miano R, van Moorselaar RJ, Mottet N, Osorio L, Pieters BR, Polascik TJ, Rastinehad AR, Salomon G, Sanchez-Salas R, Schostak M, Sentker L, Tay KJ, Varkarakis IM, Villers A, Walz J, De la Rosette JJ. Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project. World J Urol. 2016 Oct;34(10):1373–1382.
Journal cover image

Published In

World J Urol

DOI

EISSN

1433-8726

Publication Date

October 2016

Volume

34

Issue

10

Start / End Page

1373 / 1382

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Surveys and Questionnaires
  • Quality of Life
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Male
  • Humans
  • Delphi Technique
  • Consensus
  • Combined Modality Therapy