Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus).

Publication ,  Journal Article
Lee, YW; Fishman, L; Kelly, JK; Willis, JH
Published in: Genetics
April 2016

Polymorphic chromosomal rearrangements can bind hundreds of genes into single genetic loci with diverse effects. Rearrangements are often associated with local adaptation and speciation and may also be an important component of genetic variation within populations. We genetically and phenotypically characterize a segregating inversion (inv6) in the Iron Mountain (IM) population of Mimulus guttatus (yellow monkeyflower). We initially mapped inv6 as a region of recombination suppression in three F2 populations resulting from crosses among IM plants. In each case, the F1 parent was heterozygous for a derived haplotype, homogenous across markers spanning over 5 Mb of chromsome 6. In the three F2 populations, inv6 reduced male and female fitness components. In addition,i nv6 carriers suffered an ∼30% loss of pollen viability in the field. Despite these costs, inv6 exists at moderate frequency (∼8%) in the natural population, suggesting counterbalancing fitness benefits that maintain the polymorphism. Across 4 years of monitoring in the field, inv6 had an overall significant positive effect on seed production (lifetime female fitness) of carriers. This benefit was particularly strong in harsh years and may be mediated (in part) by strong positive effects on flower production. These data suggest that opposing fitness effects maintain an intermediate frequency, and as a consequence, inv6 generates inbreeding depression and high genetic variance. We discuss these findings in relation to the theory of inbreeding depression and the maintenance of fitness variation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Genetics

DOI

EISSN

1943-2631

ISSN

0016-6731

Publication Date

April 2016

Volume

202

Issue

4

Start / End Page

1473 / 1484

Related Subject Headings

  • Translocation, Genetic
  • Recombination, Genetic
  • Quantitative Trait Loci
  • Polymorphism, Genetic
  • Phenotype
  • Mimulus
  • Inbreeding Depression
  • Heterozygote
  • Genotype
  • Genetics, Population
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, Y. W., Fishman, L., Kelly, J. K., & Willis, J. H. (2016). A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus). Genetics, 202(4), 1473–1484. https://doi.org/10.1534/genetics.115.183566
Lee, Young Wha, Lila Fishman, John K. Kelly, and John H. Willis. “A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus).Genetics 202, no. 4 (April 2016): 1473–84. https://doi.org/10.1534/genetics.115.183566.
Lee YW, Fishman L, Kelly JK, Willis JH. A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus). Genetics. 2016 Apr;202(4):1473–84.
Lee, Young Wha, et al. “A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus).Genetics, vol. 202, no. 4, Apr. 2016, pp. 1473–84. Epmc, doi:10.1534/genetics.115.183566.
Lee YW, Fishman L, Kelly JK, Willis JH. A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus). Genetics. 2016 Apr;202(4):1473–1484.

Published In

Genetics

DOI

EISSN

1943-2631

ISSN

0016-6731

Publication Date

April 2016

Volume

202

Issue

4

Start / End Page

1473 / 1484

Related Subject Headings

  • Translocation, Genetic
  • Recombination, Genetic
  • Quantitative Trait Loci
  • Polymorphism, Genetic
  • Phenotype
  • Mimulus
  • Inbreeding Depression
  • Heterozygote
  • Genotype
  • Genetics, Population