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Design and Implementation of the International Genetics and Translational Research in Transplantation Network.

Publication ,  Journal Article
International Genetics & Translational Research in Transplantation Network (iGeneTRAiN),
Published in: Transplantation
November 2015

BACKGROUND: Genetic association studies of transplantation outcomes have been hampered by small samples and highly complex multifactorial phenotypes, hindering investigations of the genetic architecture of a range of comorbidities which significantly impact graft and recipient life expectancy. We describe here the rationale and design of the International Genetics & Translational Research in Transplantation Network. The network comprises 22 studies to date, including 16494 transplant recipients and 11669 donors, of whom more than 5000 are of non-European ancestry, all of whom have existing genomewide genotype data sets. METHODS: We describe the rich genetic and phenotypic information available in this consortium comprising heart, kidney, liver, and lung transplant cohorts. RESULTS: We demonstrate significant power in International Genetics & Translational Research in Transplantation Network to detect main effect association signals across regions such as the MHC region as well as genomewide for transplant outcomes that span all solid organs, such as graft survival, acute rejection, new onset of diabetes after transplantation, and for delayed graft function in kidney only. CONCLUSIONS: This consortium is designed and statistically powered to deliver pioneering insights into the genetic architecture of transplant-related outcomes across a range of different solid-organ transplant studies. The study design allows a spectrum of analyses to be performed including recipient-only analyses, donor-recipient HLA mismatches with focus on loss-of-function variants and nonsynonymous single nucleotide polymorphisms.

Duke Scholars

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Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

November 2015

Volume

99

Issue

11

Start / End Page

2401 / 2412

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Translational Research, Biomedical
  • Surgery
  • Sample Size
  • Risk Factors
  • Research Design
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Organ Transplantation
  • Models, Organizational
 

Citation

APA
Chicago
ICMJE
MLA
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International Genetics & Translational Research in Transplantation Network (iGeneTRAiN), . (2015). Design and Implementation of the International Genetics and Translational Research in Transplantation Network. Transplantation, 99(11), 2401–2412. https://doi.org/10.1097/TP.0000000000000913
International Genetics & Translational Research in Transplantation Network (iGeneTRAiN), Steven D. “Design and Implementation of the International Genetics and Translational Research in Transplantation Network.Transplantation 99, no. 11 (November 2015): 2401–12. https://doi.org/10.1097/TP.0000000000000913.
International Genetics & Translational Research in Transplantation Network (iGeneTRAiN). Design and Implementation of the International Genetics and Translational Research in Transplantation Network. Transplantation. 2015 Nov;99(11):2401–12.
International Genetics & Translational Research in Transplantation Network (iGeneTRAiN), Steven D. “Design and Implementation of the International Genetics and Translational Research in Transplantation Network.Transplantation, vol. 99, no. 11, Nov. 2015, pp. 2401–12. Pubmed, doi:10.1097/TP.0000000000000913.
International Genetics & Translational Research in Transplantation Network (iGeneTRAiN). Design and Implementation of the International Genetics and Translational Research in Transplantation Network. Transplantation. 2015 Nov;99(11):2401–2412.

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

November 2015

Volume

99

Issue

11

Start / End Page

2401 / 2412

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Translational Research, Biomedical
  • Surgery
  • Sample Size
  • Risk Factors
  • Research Design
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Organ Transplantation
  • Models, Organizational