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Irradiation and immunotherapy: From concept to the clinic.

Publication ,  Journal Article
Salama, AKS; Postow, MA; Salama, JK
Published in: Cancer
June 1, 2016

In recent years, an increased understanding of T-cell-regulatory mechanisms has led to the development of a novel class of immune-checkpoint inhibitors that have robust clinical activity against a broad array of malignancies-even those that historically were not believed to be sensitive to immune therapy. With this, there has been renewed interest in the potential for synergy with more traditional forms of anticancer therapy like radiation therapy (RT). The role of RT in palliation or as definitive treatment for certain malignancies has been well established. Yet, in recent years, the concept has come to light that RT could be an attractive partner for use in combination with other immunotherapies. The effects of RT include not only control of an irradiated tumor but also multiple immunomodulatory effects on both the tumor and the microenvironment, priming tumors for an immune-mediated response. Herein, the authors summarize relevant preclinical data and rationale supporting the synergy of combined RT and immunotherapy and highlight recent clinical work on promising combination strategies. Cancer 2016;122:1659-71. © 2016 American Cancer Society.

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

June 1, 2016

Volume

122

Issue

11

Start / End Page

1659 / 1671

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocytes
  • Radiotherapy
  • Radiosurgery
  • Radiation Tolerance
  • Oncology & Carcinogenesis
  • Neoplasms
  • Ipilimumab
  • Immunotherapy
  • Immunosuppression Therapy
 

Citation

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Salama, A. K. S., Postow, M. A., & Salama, J. K. (2016). Irradiation and immunotherapy: From concept to the clinic. Cancer, 122(11), 1659–1671. https://doi.org/10.1002/cncr.29889
Salama, April K. S., Michael A. Postow, and Joseph K. Salama. “Irradiation and immunotherapy: From concept to the clinic.Cancer 122, no. 11 (June 1, 2016): 1659–71. https://doi.org/10.1002/cncr.29889.
Salama AKS, Postow MA, Salama JK. Irradiation and immunotherapy: From concept to the clinic. Cancer. 2016 Jun 1;122(11):1659–71.
Salama, April K. S., et al. “Irradiation and immunotherapy: From concept to the clinic.Cancer, vol. 122, no. 11, June 2016, pp. 1659–71. Pubmed, doi:10.1002/cncr.29889.
Salama AKS, Postow MA, Salama JK. Irradiation and immunotherapy: From concept to the clinic. Cancer. 2016 Jun 1;122(11):1659–1671.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

June 1, 2016

Volume

122

Issue

11

Start / End Page

1659 / 1671

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocytes
  • Radiotherapy
  • Radiosurgery
  • Radiation Tolerance
  • Oncology & Carcinogenesis
  • Neoplasms
  • Ipilimumab
  • Immunotherapy
  • Immunosuppression Therapy