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Immune plexins and semaphorins: old proteins, new immune functions.

Publication ,  Journal Article
Roney, K; Holl, E; Ting, J
Published in: Protein Cell
January 2013

Plexins and semaphorins are a large family of proteins that are involved in cell movement and response. The importance of plexins and semaphorins has been emphasized by their discovery in many organ systems including the nervous (Nkyimbeng-Takwi and Chapoval, 2011; McCormick and Leipzig, 2012; Yaron and Sprinzak, 2012), epithelial (Miao et al., 1999; Fujii et al., 2002), and immune systems (Takamatsu and Kumanogoh, 2012) as well as diverse cell processes including angiogenesis (Serini et al., 2009; Sakurai et al., 2012), embryogenesis (Perala et al., 2012), and cancer (Potiron et al., 2009; Micucci et al., 2010). Plexins and semaphorins are transmembrane proteins that share a conserved extracellular semaphorin domain (Hota and Buck, 2012). The plexins and semaphorins are divided into four and eight subfamilies respectively based on their structural homology. Semaphorins are relatively small proteins containing the extracellular semaphorin domain and short intracellular tails. Plexins contain the semaphorin domain and long intracellular tails (Hota and Buck, 2012). The majority of plexin and semaphorin research has focused on the nervous system, particularly the developing nervous system, where these proteins are found to mediate many common neuronal cell processes including cell movement, cytoskeletal rearrangement, and signal transduction (Choi et al., 2008; Takamatsu et al., 2010). Their roles in the immune system are the focus of this review.

Duke Scholars

Published In

Protein Cell

DOI

EISSN

1674-8018

Publication Date

January 2013

Volume

4

Issue

1

Start / End Page

17 / 26

Location

Germany

Related Subject Headings

  • Semaphorins
  • Nerve Tissue Proteins
  • Immunity
  • Humans
  • Cell Adhesion Molecules
  • Animals
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

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MLA
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Roney, K., Holl, E., & Ting, J. (2013). Immune plexins and semaphorins: old proteins, new immune functions. Protein Cell, 4(1), 17–26. https://doi.org/10.1007/s13238-012-2108-4
Roney, Kelly, Eda Holl, and Jenny Ting. “Immune plexins and semaphorins: old proteins, new immune functions.Protein Cell 4, no. 1 (January 2013): 17–26. https://doi.org/10.1007/s13238-012-2108-4.
Roney K, Holl E, Ting J. Immune plexins and semaphorins: old proteins, new immune functions. Protein Cell. 2013 Jan;4(1):17–26.
Roney, Kelly, et al. “Immune plexins and semaphorins: old proteins, new immune functions.Protein Cell, vol. 4, no. 1, Jan. 2013, pp. 17–26. Pubmed, doi:10.1007/s13238-012-2108-4.
Roney K, Holl E, Ting J. Immune plexins and semaphorins: old proteins, new immune functions. Protein Cell. 2013 Jan;4(1):17–26.
Journal cover image

Published In

Protein Cell

DOI

EISSN

1674-8018

Publication Date

January 2013

Volume

4

Issue

1

Start / End Page

17 / 26

Location

Germany

Related Subject Headings

  • Semaphorins
  • Nerve Tissue Proteins
  • Immunity
  • Humans
  • Cell Adhesion Molecules
  • Animals
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology