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Statin therapy reduces growth of abdominal aortic aneurysms.

Publication ,  Journal Article
Karrowni, W; Dughman, S; Hajj, GP; Miller, FJ
Published in: J Investig Med
December 2011

BACKGROUND: The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). METHODS: We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance. RESULTS: Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors. CONCLUSIONS: To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.

Duke Scholars

Published In

J Investig Med

DOI

EISSN

1708-8267

Publication Date

December 2011

Volume

59

Issue

8

Start / End Page

1239 / 1243

Location

England

Related Subject Headings

  • Multivariate Analysis
  • Male
  • Linear Models
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • General Clinical Medicine
  • Female
  • Aortic Aneurysm, Abdominal
  • Aged
  • 3202 Clinical sciences
 

Citation

APA
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ICMJE
MLA
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Karrowni, W., Dughman, S., Hajj, G. P., & Miller, F. J. (2011). Statin therapy reduces growth of abdominal aortic aneurysms. J Investig Med, 59(8), 1239–1243. https://doi.org/10.2130/JIM.0b013e31823548e8
Karrowni, Wassef, Saadeddine Dughman, Georges P. Hajj, and Francis J. Miller. “Statin therapy reduces growth of abdominal aortic aneurysms.J Investig Med 59, no. 8 (December 2011): 1239–43. https://doi.org/10.2130/JIM.0b013e31823548e8.
Karrowni W, Dughman S, Hajj GP, Miller FJ. Statin therapy reduces growth of abdominal aortic aneurysms. J Investig Med. 2011 Dec;59(8):1239–43.
Karrowni, Wassef, et al. “Statin therapy reduces growth of abdominal aortic aneurysms.J Investig Med, vol. 59, no. 8, Dec. 2011, pp. 1239–43. Pubmed, doi:10.2130/JIM.0b013e31823548e8.
Karrowni W, Dughman S, Hajj GP, Miller FJ. Statin therapy reduces growth of abdominal aortic aneurysms. J Investig Med. 2011 Dec;59(8):1239–1243.

Published In

J Investig Med

DOI

EISSN

1708-8267

Publication Date

December 2011

Volume

59

Issue

8

Start / End Page

1239 / 1243

Location

England

Related Subject Headings

  • Multivariate Analysis
  • Male
  • Linear Models
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • General Clinical Medicine
  • Female
  • Aortic Aneurysm, Abdominal
  • Aged
  • 3202 Clinical sciences