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Ankyrin-B in lens architecture and biomechanics: Just not tethering but more.

Publication ,  Journal Article
Rao, PV; Maddala, R
Published in: Bioarchitecture
2016

The ankyrins are a family of well-characterized metazoan adaptor proteins that play a key role in linking various membrane-spanning proteins to the underlying spectrin-actin cytoskeleton; a mechanistic understanding of their role in tissue architecture and mechanics, however, remains elusive. Here we comment on a recent study demonstrating a key role for ankyrin-B in maintaining the hexagonal shape and radial alignment of ocular lens fiber cells by regulating the membrane organization of periaxin, dystrophins/dystroglycan, NrCAM and spectrin-actin network of proteins, and revealing that ankyrin-B deficiency impairs fiber cell shape and mechanical properties of the ocular lens. These observations indicate that ankyrin-B plays an important role in maintaining tissue cytoarchitecture, cell shape and biomechanical properties via engaging in key protein: protein interactions required for membrane anchoring and organization of the spectrin-actin skeleton, scaffolding proteins and cell adhesive proteins.

Duke Scholars

Published In

Bioarchitecture

DOI

EISSN

1949-100X

Publication Date

2016

Volume

6

Issue

2

Start / End Page

39 / 45

Location

United States

Related Subject Headings

  • Membrane Proteins
  • Lens, Crystalline
  • Epithelial Cells
  • Ankyrins
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Rao, P. V., & Maddala, R. (2016). Ankyrin-B in lens architecture and biomechanics: Just not tethering but more. Bioarchitecture, 6(2), 39–45. https://doi.org/10.1080/19490992.2016.1156284
Rao, Ponugoti Vasantha, and Rupalatha Maddala. “Ankyrin-B in lens architecture and biomechanics: Just not tethering but more.Bioarchitecture 6, no. 2 (2016): 39–45. https://doi.org/10.1080/19490992.2016.1156284.
Rao PV, Maddala R. Ankyrin-B in lens architecture and biomechanics: Just not tethering but more. Bioarchitecture. 2016;6(2):39–45.
Rao, Ponugoti Vasantha, and Rupalatha Maddala. “Ankyrin-B in lens architecture and biomechanics: Just not tethering but more.Bioarchitecture, vol. 6, no. 2, 2016, pp. 39–45. Pubmed, doi:10.1080/19490992.2016.1156284.
Rao PV, Maddala R. Ankyrin-B in lens architecture and biomechanics: Just not tethering but more. Bioarchitecture. 2016;6(2):39–45.

Published In

Bioarchitecture

DOI

EISSN

1949-100X

Publication Date

2016

Volume

6

Issue

2

Start / End Page

39 / 45

Location

United States

Related Subject Headings

  • Membrane Proteins
  • Lens, Crystalline
  • Epithelial Cells
  • Ankyrins
  • Animals