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Delta 9 -tetrahydrocannabinol and ethanol: differential effects on sympathetic activity in differing environmental setting.

Publication ,  Journal Article
Ng, LK; Lamprecht, F; Williams, RB; Kopin, IJ
Published in: Science
June 29, 1973

Serum dopamine beta-hydroxylase activity, a useful biochemical index of peripheral sympathetic nervous activity, was measured in rats treated with Delta(9)-tetrahydrocannabinol or ethanol or both substances. After 7 days of treatment with either substance, serum dopamine beta-hydroxylase activity decreased significantly. Combined treatment with both agents enhanced the effects of each given alone. In rats subjected to immobilization stress, treatment with Delta(9)- tetrahydrocannabinol appeared to potentiate the stress-induced increase in serum enzyme activity. Treatment with ethanol, with or without Delta(9)-tetrahydrocannabinol, effectively blocked this increase in enzyme activity. These results show that both substances have significant effects on the sympathetic nervous system which are critically influenced by environmental setting.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 29, 1973

Volume

180

Issue

4093

Start / End Page

1368 / 1369

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Sympathetic Nervous System
  • Stress, Physiological
  • Rats
  • Polyethylenes
  • Immobilization
  • Humans
  • Glycols
  • General Science & Technology
  • Drug Synergism
 

Citation

APA
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ICMJE
MLA
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Ng, L. K., Lamprecht, F., Williams, R. B., & Kopin, I. J. (1973). Delta 9 -tetrahydrocannabinol and ethanol: differential effects on sympathetic activity in differing environmental setting. Science, 180(4093), 1368–1369. https://doi.org/10.1126/science.180.4093.1368
Ng, L. K., F. Lamprecht, R. B. Williams, and I. J. Kopin. “Delta 9 -tetrahydrocannabinol and ethanol: differential effects on sympathetic activity in differing environmental setting.Science 180, no. 4093 (June 29, 1973): 1368–69. https://doi.org/10.1126/science.180.4093.1368.
Ng LK, Lamprecht F, Williams RB, Kopin IJ. Delta 9 -tetrahydrocannabinol and ethanol: differential effects on sympathetic activity in differing environmental setting. Science. 1973 Jun 29;180(4093):1368–9.
Ng, L. K., et al. “Delta 9 -tetrahydrocannabinol and ethanol: differential effects on sympathetic activity in differing environmental setting.Science, vol. 180, no. 4093, June 1973, pp. 1368–69. Pubmed, doi:10.1126/science.180.4093.1368.
Ng LK, Lamprecht F, Williams RB, Kopin IJ. Delta 9 -tetrahydrocannabinol and ethanol: differential effects on sympathetic activity in differing environmental setting. Science. 1973 Jun 29;180(4093):1368–1369.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 29, 1973

Volume

180

Issue

4093

Start / End Page

1368 / 1369

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Sympathetic Nervous System
  • Stress, Physiological
  • Rats
  • Polyethylenes
  • Immobilization
  • Humans
  • Glycols
  • General Science & Technology
  • Drug Synergism