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Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.

Publication ,  Journal Article
Király, MA; Campbell, J; Park, E; Bates, HE; Yue, JTY; Rao, V; Matthews, SG; Bikopoulos, G; Rozakis-Adcock, M; Giacca, A; Vranic, M; Riddell, MC
Published in: Am J Physiol Endocrinol Metab
March 2010

Stress-activated systems and oxidative stress are involved in insulin resistance, which, along with beta-cell failure, contribute to the development of type 2 diabetes mellitus (T2DM). Exercise improves insulin resistance and glucose tolerance, and these adaptations may, in part, be related to reductions in inflammation and oxidative stress. We investigated circulating and tissue-specific markers of inflammation and oxidative stress and insulin-signaling pathways in a rodent model of T2DM, the Zucker diabetic fatty rat, with and without voluntary exercise. At 5 wk of age, Zucker diabetic fatty rats (n = 8-9/group) were divided into basal (B), voluntary exercise (E), and sedentary control (S) groups. B rats were euthanized at 6 wk of age, and S and E rats were euthanized 10 wk later. E rats ran approximately 5 km/day, which improved insulin sensitivity and maintained fed and fasted glucose levels and glucose tolerance. Ten weeks of exercise also decreased whole body markers of inflammation and oxidative stress in plasma and liver, including lowered circulating IL-6, haptoglobin, and malondialdehyde levels, hepatic protein oxidation, and phosphorylated JNK, the latter indicating decreased JNK activity. Hepatic phosphoenolpyruvate carboxykinase levels and Ser(307)-phosphorylated insulin receptor substrate-1 were also reduced in E compared with S rats. In summary, we show that, in a rodent model of T2DM, voluntary exercise decreases circulating markers of inflammation and oxidative stress and lowers hepatic JNK activation and Ser(307)-phosphorylated insulin receptor substrate-1. These changes in oxidative stress markers and inflammation are associated with decreased hyperglycemia and insulin resistance and reduced expression of the main gluconeogenic enzyme phosphoenolpyruvate carboxykinase.

Duke Scholars

Published In

Am J Physiol Endocrinol Metab

DOI

EISSN

1522-1555

Publication Date

March 2010

Volume

298

Issue

3

Start / End Page

E671 / E682

Location

United States

Related Subject Headings

  • Serine
  • Rats, Zucker
  • Rats
  • Physical Conditioning, Animal
  • Phosphorylation
  • Oxidative Stress
  • Male
  • Liver
  • JNK Mitogen-Activated Protein Kinases
  • Insulin Receptor Substrate Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Király, M. A., Campbell, J., Park, E., Bates, H. E., Yue, J. T. Y., Rao, V., … Riddell, M. C. (2010). Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Am J Physiol Endocrinol Metab, 298(3), E671–E682. https://doi.org/10.1152/ajpendo.90575.2008
Király, Michael A., Jon Campbell, Edward Park, Holly E. Bates, Jessica T. Y. Yue, Venket Rao, Stephen G. Matthews, et al. “Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.Am J Physiol Endocrinol Metab 298, no. 3 (March 2010): E671–82. https://doi.org/10.1152/ajpendo.90575.2008.
Király MA, Campbell J, Park E, Bates HE, Yue JTY, Rao V, et al. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E671–82.
Király, Michael A., et al. “Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.Am J Physiol Endocrinol Metab, vol. 298, no. 3, Mar. 2010, pp. E671–82. Pubmed, doi:10.1152/ajpendo.90575.2008.
Király MA, Campbell J, Park E, Bates HE, Yue JTY, Rao V, Matthews SG, Bikopoulos G, Rozakis-Adcock M, Giacca A, Vranic M, Riddell MC. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E671–E682.

Published In

Am J Physiol Endocrinol Metab

DOI

EISSN

1522-1555

Publication Date

March 2010

Volume

298

Issue

3

Start / End Page

E671 / E682

Location

United States

Related Subject Headings

  • Serine
  • Rats, Zucker
  • Rats
  • Physical Conditioning, Animal
  • Phosphorylation
  • Oxidative Stress
  • Male
  • Liver
  • JNK Mitogen-Activated Protein Kinases
  • Insulin Receptor Substrate Proteins