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Genetic dissection of late-life fertility in Caenorhabditis elegans.

Publication ,  Journal Article
Mendenhall, AR; Wu, D; Park, S-K; Cypser, JR; Tedesco, PM; Link, CD; Phillips, PC; Johnson, TE
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
August 2011

The large post-reproductive life span reported for the free-living hermaphroditic nematode, Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-reproduction, seems at odds with evolutionary theory. Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of information. This does not seem a suitable explanation for C elegans. Previous reports have shown that C elegans can regain fertility when mated after the self-fertile period but did not report the functional limits. Here, we report the functional life span of the C elegans germ line when mating with males. We show that C elegans can regain fertility late in life (significantly later than in previous reports) and that the end of this period corresponds quite well to its 3-week total life span. Genetic analysis reveals that late-life fertility is controlled by conserved pathways involved with aging and dietary restriction.

Duke Scholars

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

August 2011

Volume

66

Issue

8

Start / End Page

842 / 854

Related Subject Headings

  • Transcription Factors
  • Reproduction
  • Mutation
  • Male
  • Longevity
  • Gonads
  • Gerontology
  • Germ Cells
  • Fertility
  • Diet
 

Citation

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MLA
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Mendenhall, A. R., Wu, D., Park, S.-K., Cypser, J. R., Tedesco, P. M., Link, C. D., … Johnson, T. E. (2011). Genetic dissection of late-life fertility in Caenorhabditis elegans. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 66(8), 842–854. https://doi.org/10.1093/gerona/glr089
Mendenhall, Alexander R., Deqing Wu, Sang-Kyu Park, James R. Cypser, Patricia M. Tedesco, Christopher D. Link, Patrick C. Phillips, and Thomas E. Johnson. “Genetic dissection of late-life fertility in Caenorhabditis elegans.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 66, no. 8 (August 2011): 842–54. https://doi.org/10.1093/gerona/glr089.
Mendenhall AR, Wu D, Park S-K, Cypser JR, Tedesco PM, Link CD, et al. Genetic dissection of late-life fertility in Caenorhabditis elegans. The journals of gerontology Series A, Biological sciences and medical sciences. 2011 Aug;66(8):842–54.
Mendenhall, Alexander R., et al. “Genetic dissection of late-life fertility in Caenorhabditis elegans.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 66, no. 8, Aug. 2011, pp. 842–54. Epmc, doi:10.1093/gerona/glr089.
Mendenhall AR, Wu D, Park S-K, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE. Genetic dissection of late-life fertility in Caenorhabditis elegans. The journals of gerontology Series A, Biological sciences and medical sciences. 2011 Aug;66(8):842–854.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

August 2011

Volume

66

Issue

8

Start / End Page

842 / 854

Related Subject Headings

  • Transcription Factors
  • Reproduction
  • Mutation
  • Male
  • Longevity
  • Gonads
  • Gerontology
  • Germ Cells
  • Fertility
  • Diet