Skip to main content

Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms.

Publication ,  Journal Article
Danziger, ZC; Grill, WM
Published in: American journal of physiology. Renal physiology
August 2016

The postvoid residual volume (PVR) is a common urodynamic parameter used to quantify the severity of lower urinary tract dysfunction. However, the serial cystometrograms that are typically used to assess bladder function in animal models make measuring PVR very difficult. Current approaches are to either remove PVR after each void to measure it, which is disruptive to the bladder, or to neglect the unknown contribution to PVR from ureter flow, which results in inaccurate estimates. We propose a procedure to estimate PVR during a serial cystometrogram that requires only a single measurement, rather than measuring after each void. Moreover, this measurement can occur at the end of the experiment such that it does not affect the bladder during data collection. We mathematically express PVR for all voids during a serial cystometrogram using a linear recurrence equation and use this equation to build an estimation procedure for PVR. Using in vivo measurements in urethane anesthetized rats and computer simulations we show that the estimation procedure is at least as accurate in determining PVR as the traditional method of measuring PVR after each void. Furthermore, we demonstrate the adverse effects of repeated PVR measurements in a common animal model of cystitis. Using the proposed procedure can increase the efficiency and accuracy of determining PVR for a serial cystometrogram and is less disruptive to the system under study. This, in turn, allows the calculation of other urodynamic parameters that are critical for research studies, including voiding efficiency and bladder capacity.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

American journal of physiology. Renal physiology

DOI

EISSN

1522-1466

ISSN

1931-857X

Publication Date

August 2016

Volume

311

Issue

2

Start / End Page

F459 / F468

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urination
  • Urinary Bladder
  • Ureter
  • Reproducibility of Results
  • Rats, Sprague-Dawley
  • Rats
  • Female
  • Cystitis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Danziger, Z. C., & Grill, W. M. (2016). Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms. American Journal of Physiology. Renal Physiology, 311(2), F459–F468. https://doi.org/10.1152/ajprenal.00516.2015
Danziger, Zachary C., and Warren M. Grill. “Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms.American Journal of Physiology. Renal Physiology 311, no. 2 (August 2016): F459–68. https://doi.org/10.1152/ajprenal.00516.2015.
Danziger ZC, Grill WM. Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms. American journal of physiology Renal physiology. 2016 Aug;311(2):F459–68.
Danziger, Zachary C., and Warren M. Grill. “Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms.American Journal of Physiology. Renal Physiology, vol. 311, no. 2, Aug. 2016, pp. F459–68. Epmc, doi:10.1152/ajprenal.00516.2015.
Danziger ZC, Grill WM. Estimating postvoid residual volume without measuring residual bladder volume during serial cystometrograms. American journal of physiology Renal physiology. 2016 Aug;311(2):F459–F468.

Published In

American journal of physiology. Renal physiology

DOI

EISSN

1522-1466

ISSN

1931-857X

Publication Date

August 2016

Volume

311

Issue

2

Start / End Page

F459 / F468

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urination
  • Urinary Bladder
  • Ureter
  • Reproducibility of Results
  • Rats, Sprague-Dawley
  • Rats
  • Female
  • Cystitis