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Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria.

Publication ,  Journal Article
Cao, Y; Ryser, MD; Payne, S; Li, B; Rao, CV; You, L
Published in: Cell
April 21, 2016

Scale invariance refers to the maintenance of a constant ratio of developing organ size to body size. Although common, its underlying mechanisms remain poorly understood. Here, we examined scaling in engineered Escherichia coli that can form self-organized core-ring patterns in colonies. We found that the ring width exhibits perfect scale invariance to the colony size. Our analysis revealed a collective space-sensing mechanism, which entails sequential actions of an integral feedback loop and an incoherent feedforward loop. The integral feedback is implemented by the accumulation of a diffusive chemical produced by a colony. This accumulation, combined with nutrient consumption, sets the timing for ring initiation. The incoherent feedforward is implemented by the opposing effects of the domain size on the rate and duration of ring maturation. This mechanism emphasizes a role of timing control in achieving robust pattern scaling and provides a new perspective in examining the phenomenon in natural systems.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 21, 2016

Volume

165

Issue

3

Start / End Page

620 / 630

Location

United States

Related Subject Headings

  • Organ Size
  • Models, Biological
  • Microbiological Phenomena
  • Feedback
  • Escherichia coli
  • Developmental Biology
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

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Cao, Y., Ryser, M. D., Payne, S., Li, B., Rao, C. V., & You, L. (2016). Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria. Cell, 165(3), 620–630. https://doi.org/10.1016/j.cell.2016.03.006
Cao, Yangxiaolu, Marc D. Ryser, Stephen Payne, Bochong Li, Christopher V. Rao, and Lingchong You. “Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria.Cell 165, no. 3 (April 21, 2016): 620–30. https://doi.org/10.1016/j.cell.2016.03.006.
Cao Y, Ryser MD, Payne S, Li B, Rao CV, You L. Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria. Cell. 2016 Apr 21;165(3):620–30.
Cao, Yangxiaolu, et al. “Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria.Cell, vol. 165, no. 3, Apr. 2016, pp. 620–30. Pubmed, doi:10.1016/j.cell.2016.03.006.
Cao Y, Ryser MD, Payne S, Li B, Rao CV, You L. Collective Space-Sensing Coordinates Pattern Scaling in Engineered Bacteria. Cell. 2016 Apr 21;165(3):620–630.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 21, 2016

Volume

165

Issue

3

Start / End Page

620 / 630

Location

United States

Related Subject Headings

  • Organ Size
  • Models, Biological
  • Microbiological Phenomena
  • Feedback
  • Escherichia coli
  • Developmental Biology
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences