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Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,393 donor cycles from the SART registry.

Publication ,  Journal Article
Acharya, KS; Keyhan, S; Acharya, CR; Yeh, JS; Provost, MP; Goldfarb, JM; Muasher, SJ
Published in: Fertil Steril
September 1, 2016

OBJECTIVE: To analyze donor oocyte cycles in the Society for Assisted Reproductive Technology (SART) registry to determine: 1) how many cycles complied with the 2009 American Society for Reproductive Medicine/SART embryo transfer guidelines; and 2) cycle outcomes according to the number of embryos transferred. For donor oocyte IVF with donor age <35 years, the consideration of single-embryo transfer was strongly recommended. DESIGN: Retrospective cohort study of United States national registry information. SETTING: Not applicable. PATIENT(S): A total of 13,393 donor-recipient cycles from 2011 to 2012. INTERVENTION(S): Embryos transferred in donor IVF cycles. MAIN OUTCOME MEASURE(S): Percentage of compliant cycles, multiple pregnancy rate. RESULT(S): There were 3,157 donor cleavage-stage transfers and 10,236 donor blastocyst transfers. In the cleavage-stage cycles, 88% met compliance criteria. The multiple pregnancy rate (MPR) was significantly higher in the noncompliant cycles. In a subanalysis of compliant cleavage-stage cycles, 91% transferred two embryos and only 9% single embryos. In those patients transferring two embryos, the MPR was significantly higher (33% vs. 1%). In blastocyst transfers, only 28% of the cycles met compliance criteria. The MPR was significantly higher in the noncompliant blastocyst cohort at 53% (compared with 2% in compliant cycles). CONCLUSION(S): The majority of donor cleavage-stage transfers are compliant with current guidelines, but the transfer of two embryos results in a significantly higher MPR compared with single-embryo transfer. The majority of donor blastocyst cycles are noncompliant, which appears to be driving an unacceptably high MPR in these cycles.

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Published In

Fertil Steril

DOI

EISSN

1556-5653

Publication Date

September 1, 2016

Volume

106

Issue

3

Start / End Page

603 / 607

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Treatment Outcome
  • Single Embryo Transfer
  • Retrospective Studies
  • Registries
  • Pregnancy, Multiple
  • Pregnancy Rate
  • Pregnancy
  • Practice Patterns, Physicians'
 

Citation

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Chicago
ICMJE
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Acharya, K. S., Keyhan, S., Acharya, C. R., Yeh, J. S., Provost, M. P., Goldfarb, J. M., & Muasher, S. J. (2016). Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,393 donor cycles from the SART registry. Fertil Steril, 106(3), 603–607. https://doi.org/10.1016/j.fertnstert.2016.04.039
Acharya, Kelly S., Sanaz Keyhan, Chaitanya R. Acharya, Jason S. Yeh, Meredith P. Provost, James M. Goldfarb, and Suheil J. Muasher. “Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,393 donor cycles from the SART registry.Fertil Steril 106, no. 3 (September 1, 2016): 603–7. https://doi.org/10.1016/j.fertnstert.2016.04.039.
Acharya KS, Keyhan S, Acharya CR, Yeh JS, Provost MP, Goldfarb JM, et al. Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,393 donor cycles from the SART registry. Fertil Steril. 2016 Sep 1;106(3):603–7.
Acharya, Kelly S., et al. “Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,393 donor cycles from the SART registry.Fertil Steril, vol. 106, no. 3, Sept. 2016, pp. 603–07. Pubmed, doi:10.1016/j.fertnstert.2016.04.039.
Acharya KS, Keyhan S, Acharya CR, Yeh JS, Provost MP, Goldfarb JM, Muasher SJ. Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,393 donor cycles from the SART registry. Fertil Steril. 2016 Sep 1;106(3):603–607.
Journal cover image

Published In

Fertil Steril

DOI

EISSN

1556-5653

Publication Date

September 1, 2016

Volume

106

Issue

3

Start / End Page

603 / 607

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Treatment Outcome
  • Single Embryo Transfer
  • Retrospective Studies
  • Registries
  • Pregnancy, Multiple
  • Pregnancy Rate
  • Pregnancy
  • Practice Patterns, Physicians'