Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer.
Publication
, Journal Article
Hashemi-Sadraei, N; Sikora, AG; Brizel, DM
Published in: Am Soc Clin Oncol Educ Book
2016
Immune surveillance is well recognized as an important mechanism to prevent development or progression of head and neck cancers. Head and neck cancer cells can escape the immune system through multiple mechanisms including development of tolerance in T cells and inhibition of T-cell-related pathways, generally referred to as checkpoint inhibitors. This article highlights advances in immuno-oncology treatment approaches in recurrent and metastatic head and neck squamous cell carcinoma. Clinical trials are discussed in detail, with an emphasis on response dynamics, oncologic efficacy, safety, and tolerability of checkpoint inhibitors. In addition, developing concepts and ongoing studies in this setting are also reviewed.
Duke Scholars
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Published In
Am Soc Clin Oncol Educ Book
DOI
EISSN
1548-8756
Publication Date
2016
Volume
35
Start / End Page
e277 / e282
Location
United States
Related Subject Headings
- T-Lymphocytes
- Programmed Cell Death 1 Receptor
- Neoplasm Recurrence, Local
- Neoplasm Metastasis
- Immunotherapy
- Humans
- Head and Neck Neoplasms
- Cell Cycle Checkpoints
- CTLA-4 Antigen
- B7-H1 Antigen
Citation
APA
Chicago
ICMJE
MLA
NLM
Hashemi-Sadraei, N., Sikora, A. G., & Brizel, D. M. (2016). Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer. Am Soc Clin Oncol Educ Book, 35, e277–e282. https://doi.org/10.14694/EDBK_157801
Hashemi-Sadraei, Nooshin, Andrew G. Sikora, and David M. Brizel. “Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer.” Am Soc Clin Oncol Educ Book 35 (2016): e277–82. https://doi.org/10.14694/EDBK_157801.
Hashemi-Sadraei N, Sikora AG, Brizel DM. Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer. Am Soc Clin Oncol Educ Book. 2016;35:e277–82.
Hashemi-Sadraei, Nooshin, et al. “Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer.” Am Soc Clin Oncol Educ Book, vol. 35, 2016, pp. e277–82. Pubmed, doi:10.14694/EDBK_157801.
Hashemi-Sadraei N, Sikora AG, Brizel DM. Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer. Am Soc Clin Oncol Educ Book. 2016;35:e277–e282.
Published In
Am Soc Clin Oncol Educ Book
DOI
EISSN
1548-8756
Publication Date
2016
Volume
35
Start / End Page
e277 / e282
Location
United States
Related Subject Headings
- T-Lymphocytes
- Programmed Cell Death 1 Receptor
- Neoplasm Recurrence, Local
- Neoplasm Metastasis
- Immunotherapy
- Humans
- Head and Neck Neoplasms
- Cell Cycle Checkpoints
- CTLA-4 Antigen
- B7-H1 Antigen