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Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users.

Publication ,  Journal Article
Meier, MH; Caspi, A; Cerdá, M; Hancox, RJ; Harrington, H; Houts, R; Poulton, R; Ramrakha, S; Thomson, WM; Moffitt, TE
Published in: JAMA psychiatry
July 2016

After major policy changes in the United States, policymakers, health care professionals, and the general public seek information about whether recreational cannabis use is associated with physical health problems later in life.To test associations between cannabis use over 20 years and a variety of physical health indexes at early midlife.Participants belonged to a representative birth cohort of 1037 individuals born in Dunedin, New Zealand, in 1972 and 1973 and followed to age 38 years, with 95% retention (the Dunedin Multidisciplinary Health and Development Study). We tested whether cannabis use from ages 18 to 38 years was associated with physical health at age 38, even after controlling for tobacco use, childhood health, and childhood socioeconomic status. We also tested whether cannabis use from ages 26 to 38 years was associated with within-individual health decline using the same measures of health at both ages.We assessed frequency of cannabis use and cannabis dependence at ages 18, 21, 26, 32, and 38 years.We obtained laboratory measures of physical health (periodontal health, lung function, systemic inflammation, and metabolic health), as well as self-reported physical health, at ages 26 and 38 years.The 1037 study participants were 51.6% male (n = 535). Of these, 484 had ever used tobacco daily and 675 had ever used cannabis. Cannabis use was associated with poorer periodontal health at age 38 years and within-individual decline in periodontal health from ages 26 to 38 years. For example, cannabis joint-years from ages 18 to 38 years was associated with poorer periodontal health at age 38 years, even after controlling for tobacco pack-years (β = 0.12; 95% CI, 0.05-0.18; P <.001). Additionally, cannabis joint-years from ages 26 to 38 years was associated with poorer periodontal health at age 38 years, even after accounting for periodontal health at age 26 years and tobacco pack-years (β = 0.10; 95% CI, 0.05-0.16; P <.001) However, cannabis use was unrelated to other physical health problems. Unlike cannabis use, tobacco use was associated with worse lung function, systemic inflammation, and metabolic health at age 38 years, as well as within-individual decline in health from ages 26 to 38 years.Cannabis use for up to 20 years is associated with periodontal disease but is not associated with other physical health problems in early midlife.

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Published In

JAMA psychiatry

DOI

EISSN

2168-6238

ISSN

2168-622X

Publication Date

July 2016

Volume

73

Issue

7

Start / End Page

731 / 740

Related Subject Headings

  • Young Adult
  • Smoking
  • Risk Assessment
  • Periodontal Diseases
  • New Zealand
  • Marijuana Abuse
  • Male
  • Longitudinal Studies
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Meier, M. H., Caspi, A., Cerdá, M., Hancox, R. J., Harrington, H., Houts, R., … Moffitt, T. E. (2016). Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users. JAMA Psychiatry, 73(7), 731–740. https://doi.org/10.1001/jamapsychiatry.2016.0637
Meier, Madeline H., Avshalom Caspi, Magdalena Cerdá, Robert J. Hancox, HonaLee Harrington, Renate Houts, Richie Poulton, Sandhya Ramrakha, W Murray Thomson, and Terrie E. Moffitt. “Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users.JAMA Psychiatry 73, no. 7 (July 2016): 731–40. https://doi.org/10.1001/jamapsychiatry.2016.0637.
Meier MH, Caspi A, Cerdá M, Hancox RJ, Harrington H, Houts R, et al. Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users. JAMA psychiatry. 2016 Jul;73(7):731–40.
Meier, Madeline H., et al. “Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users.JAMA Psychiatry, vol. 73, no. 7, July 2016, pp. 731–40. Epmc, doi:10.1001/jamapsychiatry.2016.0637.
Meier MH, Caspi A, Cerdá M, Hancox RJ, Harrington H, Houts R, Poulton R, Ramrakha S, Thomson WM, Moffitt TE. Associations Between Cannabis Use and Physical Health Problems in Early Midlife: A Longitudinal Comparison of Persistent Cannabis vs Tobacco Users. JAMA psychiatry. 2016 Jul;73(7):731–740.

Published In

JAMA psychiatry

DOI

EISSN

2168-6238

ISSN

2168-622X

Publication Date

July 2016

Volume

73

Issue

7

Start / End Page

731 / 740

Related Subject Headings

  • Young Adult
  • Smoking
  • Risk Assessment
  • Periodontal Diseases
  • New Zealand
  • Marijuana Abuse
  • Male
  • Longitudinal Studies
  • Humans
  • Female