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Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Publication ,  Journal Article
Cannioto, RA; LaMonte, MJ; Kelemen, LE; Risch, HA; Eng, KH; Minlikeeva, AN; Hong, C-C; Szender, JB; Sucheston-Campbell, L; Joseph, JM; Dörk, T ...
Published in: Br J Cancer
June 28, 2016

BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. METHODS: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. RESULTS: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. CONCLUSION: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

June 28, 2016

Volume

115

Issue

1

Start / End Page

95 / 101

Location

England

Related Subject Headings

  • Risk Factors
  • Recreation
  • Proportional Hazards Models
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans
  • Female
  • Exercise
 

Citation

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Cannioto, R. A., LaMonte, M. J., Kelemen, L. E., Risch, H. A., Eng, K. H., Minlikeeva, A. N., … Moysich, K. B. (2016). Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium. Br J Cancer, 115(1), 95–101. https://doi.org/10.1038/bjc.2016.153
Cannioto, Rikki A., Michael J. LaMonte, Linda E. Kelemen, Harvey A. Risch, Kevin H. Eng, Albina N. Minlikeeva, Chi-Chen Hong, et al. “Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.Br J Cancer 115, no. 1 (June 28, 2016): 95–101. https://doi.org/10.1038/bjc.2016.153.
Cannioto RA, LaMonte MJ, Kelemen LE, Risch HA, Eng KH, Minlikeeva AN, et al. Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium. Br J Cancer. 2016 Jun 28;115(1):95–101.
Cannioto, Rikki A., et al. “Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.Br J Cancer, vol. 115, no. 1, June 2016, pp. 95–101. Pubmed, doi:10.1038/bjc.2016.153.
Cannioto RA, LaMonte MJ, Kelemen LE, Risch HA, Eng KH, Minlikeeva AN, Hong C-C, Szender JB, Sucheston-Campbell L, Joseph JM, Berchuck A, Chang-Claude J, Cramer DW, DeFazio A, Diergaarde B, Dörk T, Doherty JA, Edwards RP, Fridley BL, Friel G, Goode EL, Goodman MT, Hillemanns P, Hogdall E, Hosono S, Kelley JL, Kjaer SK, Klapdor R, Matsuo K, Odunsi K, Nagle CM, Olsen CM, Paddock LE, Pearce CL, Pike MC, Rossing MA, Schmalfeldt B, Segal BH, Szamreta EA, Thompson PJ, Tseng C-C, Vierkant R, Schildkraut JM, Wentzensen N, Wicklund KG, Winham SJ, Wu AH, Modugno F, Ness RB, Jensen A, Webb PM, Terry K, Bandera EV, Moysich KB. Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium. Br J Cancer. 2016 Jun 28;115(1):95–101.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

June 28, 2016

Volume

115

Issue

1

Start / End Page

95 / 101

Location

England

Related Subject Headings

  • Risk Factors
  • Recreation
  • Proportional Hazards Models
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans
  • Female
  • Exercise