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Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.

Publication ,  Journal Article
Kwok, KWH; Dong, W; Marinakos, SM; Liu, J; Chilkoti, A; Wiesner, MR; Chernick, M; Hinton, DE
Published in: Nanotoxicology
November 2016

Silver nanoparticles (AgNPs) have been increasingly commercialized and their release into the environment is imminent. Toxicity of AgNP has been studied with a wide spectrum of organisms, yet the mechanism of toxicity remains largely unknown. This study systematically compared toxicity of 10 AgNPs of different particle diameters and coatings to Japanese medaka (Oryzias latipes) larvae to understand how characteristics of AgNP relate to toxicity. Dissolution of AgNPs was largely dependent on particle size, but their aggregation behavior and toxicity were more dependent on coating materials. 96 h lethal concentration 50% (LC50) values correlated with AgNP aggregate size rather than size of individual nanoparticles. Of the AgNPs studied, the dissolved Ag concentration in the test suspensions did not account for all of the observed toxicity, indicating the role of NP-specific characteristics in resultant toxicity. Exposure to AgNP led to decrease of sodium concentration in the tissue and increased expression of Na(+)/K(+ )ATPase. Gene expression patterns also suggested that toxicity was related to disruption of sodium regulation and not to oxidative stress.

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Published In

Nanotoxicology

DOI

EISSN

1743-5404

ISSN

1743-5390

Publication Date

November 2016

Volume

10

Issue

9

Start / End Page

1306 / 1317

Related Subject Headings

  • Water Pollutants, Chemical
  • Toxicology
  • Surface Properties
  • Sodium
  • Silver Nitrate
  • Silver
  • Povidone
  • Particle Size
  • Oxidative Stress
  • Oryzias
 

Citation

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Kwok, K. W. H., Dong, W., Marinakos, S. M., Liu, J., Chilkoti, A., Wiesner, M. R., … Hinton, D. E. (2016). Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation. Nanotoxicology, 10(9), 1306–1317. https://doi.org/10.1080/17435390.2016.1206150
Kwok, Kevin W. H., Wu Dong, Stella M. Marinakos, Jie Liu, Ashutosh Chilkoti, Mark R. Wiesner, Melissa Chernick, and David E. Hinton. “Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.Nanotoxicology 10, no. 9 (November 2016): 1306–17. https://doi.org/10.1080/17435390.2016.1206150.
Kwok KWH, Dong W, Marinakos SM, Liu J, Chilkoti A, Wiesner MR, et al. Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation. Nanotoxicology. 2016 Nov;10(9):1306–17.
Kwok, Kevin W. H., et al. “Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.Nanotoxicology, vol. 10, no. 9, Nov. 2016, pp. 1306–17. Epmc, doi:10.1080/17435390.2016.1206150.
Kwok KWH, Dong W, Marinakos SM, Liu J, Chilkoti A, Wiesner MR, Chernick M, Hinton DE. Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation. Nanotoxicology. 2016 Nov;10(9):1306–1317.

Published In

Nanotoxicology

DOI

EISSN

1743-5404

ISSN

1743-5390

Publication Date

November 2016

Volume

10

Issue

9

Start / End Page

1306 / 1317

Related Subject Headings

  • Water Pollutants, Chemical
  • Toxicology
  • Surface Properties
  • Sodium
  • Silver Nitrate
  • Silver
  • Povidone
  • Particle Size
  • Oxidative Stress
  • Oryzias