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Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.

Publication ,  Journal Article
Wu, Z; Cunefare, D; Chiu, E; Luu, CD; Ayton, LN; Toth, CA; Farsiu, S; Guymer, RH
Published in: Invest Ophthalmol Vis Sci
July 1, 2016

PURPOSE: To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD. METHODS: Forty-one AMD eyes underwent microperimetry testing and SD-OCT scans over a 12-month period at 6-month intervals. Microstructural parameters analyzed include the retinal pigment epithelium-drusen complex (RPEDC) layer thickness, number of hyperreflective foci (HF) and their inner retinal migration (represented by a weighted axial distribution score; AxD), and the number of atrophic areas. RESULTS: Microperimetric sensitivity was 0.29 dB (95% confidence interval [CI] = -0.38 to -0.20 dB, P < 0.001) and 0.13 dB (95% CI = -0.22 to -0.03 dB, P = 0.008) lower in each sector for every 10-μm higher RPEDC layer thickness and 1-HF present, but was not associated with the AxD score or the number of atrophic areas present (P ≤ 0.464). However, each 10-μm greater RPEDC layer thickness and 1-HF present was not independently associated with a further decline in sensitivity (-0.08 dB/year, 95% CI = -0.24 to 0.07 dB/year, P = 0.288 and 0.09 dB/year, 95% CI = -0.06 to 0.24 dB/year, P = 0.242, respectively) over time when accounting for the association between RPEDC layer thickness and number of HF with microperimetric sensitivity. CONCLUSIONS: Longitudinal changes in mesopic visual function measured on microperimetry paralleled changes in the microstructural changes over a 12-month time frame, without any changes occurring independent of the associations between structure and function alone.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2016

Volume

57

Issue

8

Start / End Page

3714 / 3722

Location

United States

Related Subject Headings

  • Visual Field Tests
  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Retinal Drusen
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Humans
 

Citation

APA
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ICMJE
MLA
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Wu, Z., Cunefare, D., Chiu, E., Luu, C. D., Ayton, L. N., Toth, C. A., … Guymer, R. H. (2016). Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci, 57(8), 3714–3722. https://doi.org/10.1167/iovs.15-18294
Wu, Zhichao, David Cunefare, Elizabeth Chiu, Chi D. Luu, Lauren N. Ayton, Cynthia A. Toth, Sina Farsiu, and Robyn H. Guymer. “Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.Invest Ophthalmol Vis Sci 57, no. 8 (July 1, 2016): 3714–22. https://doi.org/10.1167/iovs.15-18294.
Wu Z, Cunefare D, Chiu E, Luu CD, Ayton LN, Toth CA, et al. Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3714–22.
Wu, Zhichao, et al. “Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.Invest Ophthalmol Vis Sci, vol. 57, no. 8, July 2016, pp. 3714–22. Pubmed, doi:10.1167/iovs.15-18294.
Wu Z, Cunefare D, Chiu E, Luu CD, Ayton LN, Toth CA, Farsiu S, Guymer RH. Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3714–3722.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2016

Volume

57

Issue

8

Start / End Page

3714 / 3722

Location

United States

Related Subject Headings

  • Visual Field Tests
  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Retinal Drusen
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Humans