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Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease.

Publication ,  Journal Article
Ajmera, V; Perito, ER; Bass, NM; Terrault, NA; Yates, KP; Gill, R; Loomba, R; Diehl, AM; Aouizerat, BE; NASH Clinical Research Network,
Published in: Hepatology
January 2017

UNLABELLED: Despite the high prevalence of nonalcoholic fatty liver disease (NAFLD), therapeutic options and noninvasive markers of disease activity and severity remain limited. We investigated the association between plasma biomarkers and liver histology in order to identify markers of disease activity and severity in patients with biopsy-proven NAFLD. Thirty-two plasma biomarkers chosen a priori as possible discriminators of NAFLD were measured in participants enrolled in the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network. Dichotomized histologic outcomes were evaluated using centrally read biopsies. Biomarkers with statistically significant associations with NAFLD histology were evaluated in multivariable models adjusted for clinical factors. Of 648 participants (74.4% white, 61.7% female, mean age 47.7 years), 58.0% had definite NASH, 55.5% had mild/no fibrosis (stage 0-1), and 44.4% had significant fibrosis (stage 2-4). Increased activated plasminogen activator inhibitor 1 had a strong association with definite NASH compared to not NASH or borderline NASH in multivariable analysis (odds ratio = 1.20, 95% confidence interval 1.08-1.34, P < 0.001). Biomarkers associated with significant fibrosis (versus mild/no fibrosis) in multivariable analysis included higher levels of interleukin-8, monocyte chemoattractant protein-1, resistin, soluble interleukin-1 receptor I, soluble interleukin-2 receptor alpha, and tumor necrosis factor alpha and lower levels of insulin-like growth factor 2. CONCLUSIONS: Specific plasma biomarkers are significantly associated with disease activity and severity of fibrosis in NAFLD and are potentially valuable tools for noninvasive stratification of patients with NAFLD and identification of targets for therapeutic intervention. (Hepatology 2017;65:65-77).

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Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

January 2017

Volume

65

Issue

1

Start / End Page

65 / 77

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Liver Diseases
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Cross-Sectional Studies
 

Citation

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Ajmera, V., Perito, E. R., Bass, N. M., Terrault, N. A., Yates, K. P., Gill, R., … NASH Clinical Research Network, . (2017). Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease. Hepatology, 65(1), 65–77. https://doi.org/10.1002/hep.28776
Ajmera, Veeral, Emily R. Perito, Nathan M. Bass, Norah A. Terrault, Katherine P. Yates, Ryan Gill, Rohit Loomba, Anna Mae Diehl, Bradley E. Aouizerat, and Bradley E. NASH Clinical Research Network. “Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease.Hepatology 65, no. 1 (January 2017): 65–77. https://doi.org/10.1002/hep.28776.
Ajmera V, Perito ER, Bass NM, Terrault NA, Yates KP, Gill R, et al. Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease. Hepatology. 2017 Jan;65(1):65–77.
Ajmera, Veeral, et al. “Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease.Hepatology, vol. 65, no. 1, Jan. 2017, pp. 65–77. Pubmed, doi:10.1002/hep.28776.
Ajmera V, Perito ER, Bass NM, Terrault NA, Yates KP, Gill R, Loomba R, Diehl AM, Aouizerat BE, NASH Clinical Research Network. Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease. Hepatology. 2017 Jan;65(1):65–77.
Journal cover image

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

January 2017

Volume

65

Issue

1

Start / End Page

65 / 77

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Liver Diseases
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Cross-Sectional Studies