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Clinical trials update: Recent and ongoing studies in anticoagulation for atrial fibrillation

Publication ,  Journal Article
Wisler, JW
Published in: Open Access Journal of Clinical Trials
January 1, 2012

Atrial fibrillation is the most common sustained cardiac arrhythmia in the adult population, with a marked increased risk associated with age. Perhaps the most devastating complications of atrial fibrillation include acute ischemic stroke or systemic embolization. Vitamin K antagonists such as warfarin have served as the primary pharmacologic agent for the prevention of these thrombotic complications. Despite the widespread use of vitamin K antagonists, their effectiveness is hindered by several factors, including delayed onset of action, multiple food and drug interactions, onerous monitoring and dosing regimens, and a narrow therapeutic window. To address these limitations, multiple novel oral anticoagulants targeting thrombin or factor Xa have progressed through clinical development or received regulatory approval for clinical use in recent years. These agents offer the potential for enhanced efficacy, as well as an improved safety profile. Here, the phase II and III clinical trial data detailing the potential risks and benefits of these agents are reviewed. © 2013 Wisler.

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Published In

Open Access Journal of Clinical Trials

DOI

EISSN

1179-1586

Publication Date

January 1, 2012

Volume

5

Issue

1

Start / End Page

101 / 110

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Wisler, J. W. (2012). Clinical trials update: Recent and ongoing studies in anticoagulation for atrial fibrillation. Open Access Journal of Clinical Trials, 5(1), 101–110. https://doi.org/10.2147/OAJCT.S49106
Wisler, J. W. “Clinical trials update: Recent and ongoing studies in anticoagulation for atrial fibrillation.” Open Access Journal of Clinical Trials 5, no. 1 (January 1, 2012): 101–10. https://doi.org/10.2147/OAJCT.S49106.
Wisler JW. Clinical trials update: Recent and ongoing studies in anticoagulation for atrial fibrillation. Open Access Journal of Clinical Trials. 2012 Jan 1;5(1):101–10.
Wisler, J. W. “Clinical trials update: Recent and ongoing studies in anticoagulation for atrial fibrillation.” Open Access Journal of Clinical Trials, vol. 5, no. 1, Jan. 2012, pp. 101–10. Scopus, doi:10.2147/OAJCT.S49106.
Wisler JW. Clinical trials update: Recent and ongoing studies in anticoagulation for atrial fibrillation. Open Access Journal of Clinical Trials. 2012 Jan 1;5(1):101–110.

Published In

Open Access Journal of Clinical Trials

DOI

EISSN

1179-1586

Publication Date

January 1, 2012

Volume

5

Issue

1

Start / End Page

101 / 110

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences