Scholars@Duke

Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma.

Publication ,  Journal Article
Lei, J-Y; Huang, J
Published in: Expert Opin Med Diagn
February 2008
Published version (DOI) Link to item

Thyroid transcription factor 1 (TTF-1) is a widely used biomarker in surgical pathology. Its nuclear staining is sensitive and specific for the diagnosis of primary pulmonary and thyroid adenocarcinoma as well as small cell carcinomas arising in many organs. The cytoplasmic staining of TTF-1 is also observed, particularly in the benign and malignant hepatic cells. It has been controversial whether TTF-1 cytoplasmic staining is reliable enough to have diagnostic value. This review focuses on this issue and explores the potential application of TTF-1 cytoplasmic staining in the differential diagnosis of hepatocellular carcinoma from other primary and metastatic malignancies in the liver. The mechanism of TTF-1 cytoplasmic staining is also discussed.

Duke Scholars

Jiaoti Huang
Author Jiaoti Huang Pathology

Published In

Expert Opin Med Diagn

DOI

10.1517/17530059.2.2.151

ISSN

1753-0059

Publication Date

February 2008

Volume

2

Issue

2

Start / End Page

151 / 159

Location

England

Related Subject Headings

  • 3207 Medical microbiology
  • 3205 Medical biochemistry and metabolomics
  • 3202 Clinical sciences
  • 1108 Medical Microbiology
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics
 

Citation

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MLA
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Lei, J.-Y., & Huang, J. (2008). Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma. Expert Opin Med Diagn, 2(2), 151–159. https://doi.org/10.1517/17530059.2.2.151
Lei, Jun-Yi, and Jiaoti Huang. “Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma.” Expert Opin Med Diagn 2, no. 2 (February 2008): 151–59. https://doi.org/10.1517/17530059.2.2.151.
Lei J-Y, Huang J. Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma. Expert Opin Med Diagn. 2008 Feb;2(2):151–9.
Lei, Jun-Yi, and Jiaoti Huang. “Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma.” Expert Opin Med Diagn, vol. 2, no. 2, Feb. 2008, pp. 151–59. Pubmed, doi:10.1517/17530059.2.2.151.
Lei J-Y, Huang J. Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma. Expert Opin Med Diagn. 2008 Feb;2(2):151–159.

Published In

Expert Opin Med Diagn

DOI

10.1517/17530059.2.2.151

ISSN

1753-0059

Publication Date

February 2008

Volume

2

Issue

2

Start / End Page

151 / 159

Location

England

Related Subject Headings

  • 3207 Medical microbiology
  • 3205 Medical biochemistry and metabolomics
  • 3202 Clinical sciences
  • 1108 Medical Microbiology
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics