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CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers.

Publication ,  Journal Article
Simon, RA; di Sant'Agnese, PA; Huang, L-S; Xu, H; Yao, JL; Yang, Q; Liang, S; Liu, J; Yu, R; Cheng, L; Oh, WK; Palapattu, GS; Wei, J; Huang, J
Published in: Hum Pathol
February 2009

Small cell neuroendocrine carcinoma of the prostate is a rare variant of prostatic cancer that shares morphologic similarity with prostatic adenocarcinoma of Gleason 5 pattern. It has also been considered morphologically and immunohistochemically indistinguishable from small cell neuroendocrine carcinomas of other origins. CD44 is a cell-surface molecule proposed to identify cancer stem/progenitor cells in prostate cancer. We performed immunohistochemical study for CD44 expression in 11 cases of prostatic small cell neuroendocrine carcinoma and compared its patterns of expression with 73 cases of prostatic adenocarcinoma and 47 cases of small cell neuroendocrine carcinomas of other organs. Strong and diffuse membrane staining for CD44 was observed in 100% of the prostatic small cell neuroendocrine carcinomas. In conventional adenocarcinomas of the prostate, positive staining was only seen in rare, scattered tumor cells; and CD44 staining was negative in most of the small cell neuroendocrine carcinomas of nonprostate origin. The difference in CD44 expression between small cell neuroendocrine carcinomas of the prostate and those of other organs are statistically significant (P < .001). Our study demonstrates the utility of immunohistochemical staining for CD44 in distinguishing prostatic small cell neuroendocrine carcinoma from its mimickers including prostatic adenocarcinoma of Gleason 5 pattern and small cell neuroendocrine carcinomas of other organs. CD44 is the first marker that shows a high degree of tissue/organ specificity for small cell neuroendocrine carcinomas. Because CD44 is a putative marker of prostate cancer stem cells, the strong and diffuse expression of CD44 and the lack of expression of prostate luminal differentiation markers androgen receptor and prostatic specific antigen in prostatic small cell neuroendocrine carcinomas suggest that the tumor cells may retain cancer stem cell features.

Duke Scholars

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

February 2009

Volume

40

Issue

2

Start / End Page

252 / 258

Location

United States

Related Subject Headings

  • Tissue Array Analysis
  • Prostatic Neoplasms
  • Pathology
  • Male
  • Immunohistochemistry
  • Hyaluronan Receptors
  • Humans
  • Diagnosis, Differential
  • Carcinoma, Small Cell
  • Carcinoma, Neuroendocrine
 

Citation

APA
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ICMJE
MLA
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Simon, R. A., di Sant’Agnese, P. A., Huang, L.-S., Xu, H., Yao, J. L., Yang, Q., … Huang, J. (2009). CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Hum Pathol, 40(2), 252–258. https://doi.org/10.1016/j.humpath.2008.07.014
Simon, Rochelle A., P Anthony di Sant’Agnese, Li-Shan Huang, Haodong Xu, Jorge L. Yao, Qi Yang, Sharon Liang, et al. “CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers.Hum Pathol 40, no. 2 (February 2009): 252–58. https://doi.org/10.1016/j.humpath.2008.07.014.
Simon RA, di Sant’Agnese PA, Huang L-S, Xu H, Yao JL, Yang Q, et al. CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Hum Pathol. 2009 Feb;40(2):252–8.
Simon, Rochelle A., et al. “CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers.Hum Pathol, vol. 40, no. 2, Feb. 2009, pp. 252–58. Pubmed, doi:10.1016/j.humpath.2008.07.014.
Simon RA, di Sant’Agnese PA, Huang L-S, Xu H, Yao JL, Yang Q, Liang S, Liu J, Yu R, Cheng L, Oh WK, Palapattu GS, Wei J, Huang J. CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Hum Pathol. 2009 Feb;40(2):252–258.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

February 2009

Volume

40

Issue

2

Start / End Page

252 / 258

Location

United States

Related Subject Headings

  • Tissue Array Analysis
  • Prostatic Neoplasms
  • Pathology
  • Male
  • Immunohistochemistry
  • Hyaluronan Receptors
  • Humans
  • Diagnosis, Differential
  • Carcinoma, Small Cell
  • Carcinoma, Neuroendocrine