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Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use.

Publication ,  Journal Article
Pacek, LR; Vandrey, R; Dermody, SS; Denlinger-Apte, RL; Lemieux, A; Tidey, JW; McClernon, FJ; Bangdiwala, AS; Drobes, DJ; al'Absi, M; Donny, EC ...
Published in: Drug Alcohol Depend
October 1, 2016

INTRODUCTION: The Family Smoking Prevention and Tobacco Control Act authorized the FDA to reduce the nicotine content in cigarettes. Research is needed to guide proposed regulations, including evaluation of consequences to public health. This study evaluated how a reduced nicotine product standard might be moderated by and impact cannabis use. METHODS: Secondary analysis of a controlled clinical trial examining the effects of nicotine content in cigarettes in adult daily smokers. Linear regression assessed whether baseline cannabis use moderated behavioral, subjective, or physiological effects of smoking very low nicotine content (VLNC) versus normal nicotine content (NNC) cigarettes. Repeated measures analysis of associations between nicotine condition and prevalence and frequency of cannabis use was completed using generalized estimating equations (GEE). RESULTS: Cannabis use did not moderate most of the following effects of VLNC cigarettes: Among cannabis users and non-users, smokers randomized to VLNC cigarettes reported lower nicotine dependence, cigarettes per day, biomarkers of nicotine exposure, and craving compared to smokers randomized to NNC cigarettes. Non-cannabis using smokers randomized to VLNC cigarettes also reported lower smoking dependence motives and had lower tobacco-specific nitrosamine exposure and total puff volume versus smokers randomized to NNC cigarettes. For cannabis users, smokers randomized to VLNC cigarettes reported decreased positive affect. VLNC cigarette use did not impact the prevalence or frequency of cannabis use. DISCUSSION: Findings provide evidence that nicotine reduction in cigarettes could have beneficial effects on cigarette smoking regardless of cannabis use. Results suggest that transitioning to VLNC cigarettes is unlikely to alter current rates of cannabis use.

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Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

October 1, 2016

Volume

167

Start / End Page

228 / 232

Location

Ireland

Related Subject Headings

  • Young Adult
  • Tobacco Use Disorder
  • Tobacco Use Cessation Devices
  • Tobacco Products
  • Substance Abuse
  • Smoking Cessation
  • Public Health
  • Prevalence
  • Nicotine
  • Motivation
 

Citation

APA
Chicago
ICMJE
MLA
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Pacek, L. R., Vandrey, R., Dermody, S. S., Denlinger-Apte, R. L., Lemieux, A., Tidey, J. W., … Donny, E. C. (2016). Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use. Drug Alcohol Depend, 167, 228–232. https://doi.org/10.1016/j.drugalcdep.2016.08.620
Pacek, Lauren R., Ryan Vandrey, Sarah S. Dermody, Rachel L. Denlinger-Apte, Andrine Lemieux, Jennifer W. Tidey, F Joseph McClernon, et al. “Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use.Drug Alcohol Depend 167 (October 1, 2016): 228–32. https://doi.org/10.1016/j.drugalcdep.2016.08.620.
Pacek LR, Vandrey R, Dermody SS, Denlinger-Apte RL, Lemieux A, Tidey JW, et al. Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use. Drug Alcohol Depend. 2016 Oct 1;167:228–32.
Pacek, Lauren R., et al. “Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use.Drug Alcohol Depend, vol. 167, Oct. 2016, pp. 228–32. Pubmed, doi:10.1016/j.drugalcdep.2016.08.620.
Pacek LR, Vandrey R, Dermody SS, Denlinger-Apte RL, Lemieux A, Tidey JW, McClernon FJ, Bangdiwala AS, Drobes DJ, al’Absi M, Strasser AA, Koopmeiners JS, Hatsukami DK, Donny EC. Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use. Drug Alcohol Depend. 2016 Oct 1;167:228–232.
Journal cover image

Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

October 1, 2016

Volume

167

Start / End Page

228 / 232

Location

Ireland

Related Subject Headings

  • Young Adult
  • Tobacco Use Disorder
  • Tobacco Use Cessation Devices
  • Tobacco Products
  • Substance Abuse
  • Smoking Cessation
  • Public Health
  • Prevalence
  • Nicotine
  • Motivation