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Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.

Publication ,  Journal Article
Huang, J; Wang, JK; Sun, Y
Published in: Curr Opin Urol
May 2013

PURPOSE OF REVIEW: This article reviews recently identified genomic mutations in prostate cancer. RECENT FINDINGS: Advanced sequencing technologies have made it possible to obtain large amounts of data on genomes and transcriptomes of cancers. Such technologies have been used to sequence prostate cancer of different stages, from treatment-naive cancers, to advanced, castration-resistant cancers to the aggressive small cell neuroendocrine carcinomas. For each category of prostate cancer, distinct and overlapping DNA sequence alterations were discovered, including point mutations, small insertions or deletions, copy number changes and chromosomal rearrangements. There appears to be a stepwise increase in genomic alterations from low risk to high risk to advanced cancers. SUMMARY: These novel findings have significantly increased our knowledge of the genetic basis of human prostate cancer and the molecular mechanisms responsible for disease progression and treatment resistance. Some of the lesions are potential therapeutic targets. Studies along this direction will eventually make it possible to design personalized management plans for individual patients.

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Published In

Curr Opin Urol

DOI

EISSN

1473-6586

Publication Date

May 2013

Volume

23

Issue

3

Start / End Page

189 / 193

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Risk Factors
  • Risk Assessment
  • Prostatic Neoplasms
  • Prognosis
  • Predictive Value of Tests
  • Precision Medicine
  • Phenotype
  • Mutation
  • Male
 

Citation

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ICMJE
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Huang, J., Wang, J. K., & Sun, Y. (2013). Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy. Curr Opin Urol, 23(3), 189–193. https://doi.org/10.1097/MOU.0b013e32835e9ef4
Huang, Jiaoti, Jason K. Wang, and Yin Sun. “Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.Curr Opin Urol 23, no. 3 (May 2013): 189–93. https://doi.org/10.1097/MOU.0b013e32835e9ef4.
Huang, Jiaoti, et al. “Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.Curr Opin Urol, vol. 23, no. 3, May 2013, pp. 189–93. Pubmed, doi:10.1097/MOU.0b013e32835e9ef4.

Published In

Curr Opin Urol

DOI

EISSN

1473-6586

Publication Date

May 2013

Volume

23

Issue

3

Start / End Page

189 / 193

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Risk Factors
  • Risk Assessment
  • Prostatic Neoplasms
  • Prognosis
  • Predictive Value of Tests
  • Precision Medicine
  • Phenotype
  • Mutation
  • Male