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Fabrication of Cell Patches Using Biodegradable Scaffolds with a Hexagonal Array of Interconnected Pores (SHAIPs).

Publication ,  Journal Article
Zhang, YS; Yao, J; Wang, LV; Xia, Y
Published in: Polymer
January 2014

Cell patches are widely used for healing injuries on the surfaces or interfaces of tissues such as those of epidermis and myocardium. Here we report a novel type of porous scaffolds made of poly(D,L-lactic-co-glycolic acid) for fabricating cell patches. The scaffolds have a single layer of spherical pores arranged in a unique hexagonal pattern and are therefore referred to as "scaffolds with a hexagonal array of interconnected pores (SHAIPs)". SHAIPs contain both uniform pores and interconnecting windows that can facilitate the exchange of biomacromolecules, ensure homogeneous cell seeding, and promote cell migration. As a proof-of-concept demonstration, we have created skeletal muscle patches with a thickness of approximately 150 μm using SHAIPs. The myoblasts seeded in the scaffolds maintained high viability and were able to differentiate into multi-nucleated myotubes. Moreover, neovasculature could efficiently develop into the patches upon subcutaneous implantation in vivo.

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Published In

Polymer

DOI

EISSN

1873-2291

ISSN

0032-3861

Publication Date

January 2014

Volume

55

Issue

1

Start / End Page

445 / 452

Related Subject Headings

  • Polymers
  • 09 Engineering
  • 03 Chemical Sciences
 

Citation

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Zhang, Y. S., Yao, J., Wang, L. V., & Xia, Y. (2014). Fabrication of Cell Patches Using Biodegradable Scaffolds with a Hexagonal Array of Interconnected Pores (SHAIPs). Polymer, 55(1), 445–452. https://doi.org/10.1016/j.polymer.2013.06.019
Zhang, Yu Shrike, Junjie Yao, Lihong V. Wang, and Younan Xia. “Fabrication of Cell Patches Using Biodegradable Scaffolds with a Hexagonal Array of Interconnected Pores (SHAIPs).Polymer 55, no. 1 (January 2014): 445–52. https://doi.org/10.1016/j.polymer.2013.06.019.
Zhang, Yu Shrike, et al. “Fabrication of Cell Patches Using Biodegradable Scaffolds with a Hexagonal Array of Interconnected Pores (SHAIPs).Polymer, vol. 55, no. 1, Jan. 2014, pp. 445–52. Epmc, doi:10.1016/j.polymer.2013.06.019.
Journal cover image

Published In

Polymer

DOI

EISSN

1873-2291

ISSN

0032-3861

Publication Date

January 2014

Volume

55

Issue

1

Start / End Page

445 / 452

Related Subject Headings

  • Polymers
  • 09 Engineering
  • 03 Chemical Sciences