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Ultrasonically encoded photoacoustic flowgraphy in biological tissue.

Publication ,  Journal Article
Wang, L; Xia, J; Yao, J; Maslov, KI; Wang, LV
Published in: Physical review letters
November 2013

Blood flow speed is an important functional parameter. Doppler ultrasound flowmetry lacks sufficient sensitivity to slow blood flow (several to tens of millimeters per second) in deep tissue. To address this challenge, we developed ultrasonically encoded photoacoustic flowgraphy combining ultrasonic thermal tagging with photoacoustic imaging. Focused ultrasound generates a confined heat source in acoustically absorptive fluid. Thermal waves propagate with the flow and are directly visualized in pseudo color using photoacoustic computed tomography. The Doppler shift is employed to calculate the flow speed. This method requires only acoustic and optical absorption, and thus is applicable to continuous fluid. A blood flow speed as low as 0.24  mm·s(-1)} was successfully measured. Deep blood flow imaging was experimentally demonstrated under 5-mm-thick chicken breast tissue.

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Published In

Physical review letters

DOI

EISSN

1079-7114

ISSN

0031-9007

Publication Date

November 2013

Volume

111

Issue

20

Start / End Page

204301

Related Subject Headings

  • Ultrasonography, Doppler
  • Photoacoustic Techniques
  • Models, Theoretical
  • Laser-Doppler Flowmetry
  • Humans
  • General Physics
  • Blood
  • 09 Engineering
  • 02 Physical Sciences
  • 01 Mathematical Sciences
 

Citation

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Wang, L., Xia, J., Yao, J., Maslov, K. I., & Wang, L. V. (2013). Ultrasonically encoded photoacoustic flowgraphy in biological tissue. Physical Review Letters, 111(20), 204301. https://doi.org/10.1103/physrevlett.111.204301
Wang, Lidai, Jun Xia, Junjie Yao, Konstantin I. Maslov, and Lihong V. Wang. “Ultrasonically encoded photoacoustic flowgraphy in biological tissue.Physical Review Letters 111, no. 20 (November 2013): 204301. https://doi.org/10.1103/physrevlett.111.204301.
Wang L, Xia J, Yao J, Maslov KI, Wang LV. Ultrasonically encoded photoacoustic flowgraphy in biological tissue. Physical review letters. 2013 Nov;111(20):204301.
Wang, Lidai, et al. “Ultrasonically encoded photoacoustic flowgraphy in biological tissue.Physical Review Letters, vol. 111, no. 20, Nov. 2013, p. 204301. Epmc, doi:10.1103/physrevlett.111.204301.
Wang L, Xia J, Yao J, Maslov KI, Wang LV. Ultrasonically encoded photoacoustic flowgraphy in biological tissue. Physical review letters. 2013 Nov;111(20):204301.

Published In

Physical review letters

DOI

EISSN

1079-7114

ISSN

0031-9007

Publication Date

November 2013

Volume

111

Issue

20

Start / End Page

204301

Related Subject Headings

  • Ultrasonography, Doppler
  • Photoacoustic Techniques
  • Models, Theoretical
  • Laser-Doppler Flowmetry
  • Humans
  • General Physics
  • Blood
  • 09 Engineering
  • 02 Physical Sciences
  • 01 Mathematical Sciences