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Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo.

Publication ,  Journal Article
Yao, J; Maslov, K; Hu, S; Wang, LV
Published in: Journal of biomedical optics
September 2009

Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells (RBCs) as an endogenic contrast agent. However, intermittent RBC flow in capillaries results in discontinuous and fragmentary capillary images. To overcome this problem, we use Evans blue (EB) dye as a contrast agent for in vivo photoacoustic imaging. EB has strong optical absorption and distributes uniformly in the blood stream by chemically binding to albumin. With the help of EB, complete and continuous microvascular networks--especially capillaries--are imaged. The diffusion dynamics of EB leaving the blood stream and the clearance dynamics of the EB-albumin complex are also quantitatively investigated.

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Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

September 2009

Volume

14

Issue

5

Start / End Page

054049

Related Subject Headings

  • Optics
  • Microscopy, Acoustic
  • Mice, Nude
  • Mice
  • Image Enhancement
  • Evans Blue
  • Contrast Media
  • Capillaries
  • Animals
  • 5102 Atomic, molecular and optical physics
 

Citation

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Yao, J., Maslov, K., Hu, S., & Wang, L. V. (2009). Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. Journal of Biomedical Optics, 14(5), 054049. https://doi.org/10.1117/1.3251044
Yao, Junjie, Konstantin Maslov, Song Hu, and Lihong V. Wang. “Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo.Journal of Biomedical Optics 14, no. 5 (September 2009): 054049. https://doi.org/10.1117/1.3251044.
Yao J, Maslov K, Hu S, Wang LV. Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. Journal of biomedical optics. 2009 Sep;14(5):054049.
Yao, Junjie, et al. “Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo.Journal of Biomedical Optics, vol. 14, no. 5, Sept. 2009, p. 054049. Epmc, doi:10.1117/1.3251044.
Yao J, Maslov K, Hu S, Wang LV. Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. Journal of biomedical optics. 2009 Sep;14(5):054049.

Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

September 2009

Volume

14

Issue

5

Start / End Page

054049

Related Subject Headings

  • Optics
  • Microscopy, Acoustic
  • Mice, Nude
  • Mice
  • Image Enhancement
  • Evans Blue
  • Contrast Media
  • Capillaries
  • Animals
  • 5102 Atomic, molecular and optical physics