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Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo.

Publication ,  Conference
Yang, Z; Chen, J; Yao, J; Lin, R; Meng, J; Liu, C; Yang, J; Li, X; Wang, L; Song, L
Published in: Optics express
January 2014

Many diseases involve either the formation of new blood vessels (e.g., tumor angiogenesis) or the damage of existing ones (e.g., diabetic retinopathy) at the microcirculation level. Optical-resolution photoacoustic microscopy (OR-PAM), capable of imaging microvessels in 3D in vivo down to individual capillaries using endogenous contrast, has the potential to reveal microvascular information critical to the diagnosis and staging of microcirculation-related diseases. In this study, we have developed a dedicated microvascular quantification (MQ) algorithm for OR-PAM to automatically quantify multiple microvascular morphological parameters in parallel, including the vessel diameter distribution, the microvessel density, the vascular tortuosity, and the fractal dimension. The algorithm has been tested on in vivo OR-PAM images of a healthy mouse, demonstrating high accuracy for microvascular segmentation and quantification. The developed MQ algorithm for OR-PAM may greatly facilitate quantitative imaging of tumor angiogenesis and many other microcirculation related diseases in vivo.

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Published In

Optics express

DOI

EISSN

1094-4087

ISSN

1094-4087

Publication Date

January 2014

Volume

22

Issue

2

Start / End Page

1500 / 1511

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Optics
  • Microvessels
  • Mice
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Elasticity Imaging Techniques
  • Animals
  • Algorithms
 

Citation

APA
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MLA
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Yang, Z., Chen, J., Yao, J., Lin, R., Meng, J., Liu, C., … Song, L. (2014). Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo. In Optics express (Vol. 22, pp. 1500–1511). https://doi.org/10.1364/oe.22.001500
Yang, Zhenyuan, Jianhua Chen, Junjie Yao, Riqiang Lin, Jing Meng, Chengbo Liu, Jinhua Yang, Xiang Li, Lihong Wang, and Liang Song. “Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo.” In Optics Express, 22:1500–1511, 2014. https://doi.org/10.1364/oe.22.001500.
Yang Z, Chen J, Yao J, Lin R, Meng J, Liu C, et al. Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo. In: Optics express. 2014. p. 1500–11.
Yang, Zhenyuan, et al. “Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo.Optics Express, vol. 22, no. 2, 2014, pp. 1500–11. Epmc, doi:10.1364/oe.22.001500.
Yang Z, Chen J, Yao J, Lin R, Meng J, Liu C, Yang J, Li X, Wang L, Song L. Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo. Optics express. 2014. p. 1500–1511.
Journal cover image

Published In

Optics express

DOI

EISSN

1094-4087

ISSN

1094-4087

Publication Date

January 2014

Volume

22

Issue

2

Start / End Page

1500 / 1511

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Optics
  • Microvessels
  • Mice
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Elasticity Imaging Techniques
  • Animals
  • Algorithms