A 3D-surface torso reconstruction method used in fluorescence molecular tomography of small animals

Objective: The CCD-based non-contact fluorescencemolecular tomography has got a rapid progress in recent years. This imaging modality needs to acquire 3D-surface of the animal imaged, which is used as the forward model in the fluorescence concentration reconstruction. Methods: We proposed a new 3D-surface reconstruction method based on the back-projection method under the white light condition. After taking the surface pictures by CCD, the slice images were reconstructed using filter back- projection method, then the edge curve of each slice was extracted, and based on the data of the edges and calibration operation, we reconstructed the 3D-surface of the animal imaged. Results: The results of both phantom simulation and animal experiment showed that the method properly reconstructed the 3D-surface of trunk of small animals. Conclusions: Compared with other methods, this method is simple and fast. Furthermore, the proposed method enables the surface imaging to be inserted into the working process of the whole FMT system without interruption.

Duke Scholars

Author Junjie Yao Biomedical Engineering